CAP-003, a CNS-targeted IV-delivered AAV Gene Therapy Developed for Patients with Parkinson’s Disease associated with GBA1 Mutations
Objective: CAP-003 is a next-generation gene therapy candidate, comprising a novel brain-tropic capsid paired with hGBA1 cargo, that was developed for administration as a single…Electrophysiological Mapping in Asleep vs. Awake DBS
Objective: We report our experience using microelectrode recording (MER) in asleep vs. awake patients for DBS targeting Background: MER has played a crucial role in…Predictors of Clinical Benefit from Adaptive DBS Compared to Conventional DBS in Parkinson’s Disease
Objective: To identify patient characteristics predicting adaptive deep brain stimulation (aDBS) superiority over conventional DBS (cDBS) in Parkinson's disease (PD). Background: Adaptive DBS, modulated in…Rescue GPi DBS for Severe Dyskinesias and Dystonia in Long-Term STN DBS Parkinson’s Patients: A Case Series
Objective: Evaluate GPi DBS as a rescue therapy for refractory dyskinesias and dystonia in long-term STN DBS patients. Background: STN DBS effectively reduces medication dependency…Prevalence of Supine Hypertension in Alpha-Synucleinopathies: a Systematic Review and Meta-Analysis
Objective: We aimed to conduct a systematic review and meta-analysis to assess the prevalence of supine hypertension (SH) in α-synucleinopathies. Background: Alpha-synucleinopathies, including Parkinson’s Disease…Impact of Sleep Disturbance and Early Morning OFF Symptoms on Health-Related Quality of Life in Advanced Parkinson’s Disease
Objective: To quantify the impact of sleep disturbance (Sd) and early morning OFF (EMO) symptoms on health-related quality of life (HRQoL) in people with advanced…Correlation between Orthostatic Hypotension and Cognitive Impairment in Parkinson’s Disease
Objective: This study aims to investigate the relationship between OH and cognitive impairment in PD patients using gray matter volume (GMV) analysis. Background: Orthostatic hypotension…Vagus nerve ultrasound and its association with non-motor symptoms in parkinson’s disease
Objective: To evaluate the vagus nerve (VN) diameter with ultrasonography in Parkinson’s disease (PD) patients compared to healthy controls and explore its relationship with non-motor…Modification of Parkinson’s Disease Сourse Using Cell Technologies
Objective: To assess the long-term results of the introduction of autologous mesenchymal stem cells (MSCs) on the intensity of motor and non-motor symptoms and on…Using R and Python for Kinematic Analysis in Robotic-Assisted Balance Training: A Review of Methodologies and Outcomes
Objective: To review the methodologies and outcomes of kinematic analysis using R and Python in robotic-assisted balance training, highlighting their role in enhancing rehabilitation strategies.…
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