Parkinson’s disease GWAS-linked SNCA carriers show slower non-motor and cognitive progression
Objective: To investigate the disease progression between SNCA rs6826785 C allele carriers and noncarriers over 5 years. Background: A genome-wide association study-linked variant (SNCA rs6826785) was shown to have…People With Parkinson’s Disease and Care Partners Experience Costly Work Productivity Loss
Objective: To evaluate work productivity loss (WPL) and associated costs among people with newly diagnosed Parkinson’s Disease (nPD), advanced PD (aPD), and care partners (CP).…Clinical Manifestations and Rate of Progression of Parkinsons Disease in Different Regions
Objective: To determine the differences in the age of onset of clinical manifestations and rate of progression of Parkinson's disease in different regions of Tajikistan.…Metabolomic Profiling in an Egyptian Cohort Reveals Altered Phenylalanine Metabolism and Suggests a Role for Trans-Cinnamate in Parkinson Disease
Objective: Investigate the associated metabolic changes in PD via a comprehensive metabolic analysis with a focus on phenylalanine (dopamine precursor) metabolism and its impact on…Decreased cholinergic activity in specific brain regions associated with slower lower limb visual choice reaction time in Parkinson’s disease: A [18F]-FEOBV PET study
Objective: To investigate the relationship between cholinergic system changes, as measured by vesicular acetylcholine transporters (VAChT) [18F] fluoroethoxybenzovesamicol ([18F] FEOBV) binding in PET, and cognitive performance, measured as…Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease
Objective: This study aims to develop patient-specific vascularized midbrain assembloids incorporating microglia to better model the neuroinflammatory environment of Parkinson’s disease (PD). By integrating vascular…Sub-grouping of Parkinson’s disease based on thalamic subnuclei volume
Objective: We aimed to categorize Parkinson’s disease (PD) using k-means clustering based on thalamic subnuclei volumes measured by structural magnetic resonance imaging (sMRI). Background: The…Clinical Profile and 18F -Fluorodopa Positron Emission Tomography (18F -DOPA PET) Findings in a Movement Disorder Clinic Patient Cohort
Objective: This study aimed to evaluate the utility of 18F -DOPA PET in patients with diagnostic uncertainty at our movement disorder clinic in India. Background:…Scans Without Evidence of Dopamine Deficiency (SWEDD) in Early-Onset Parkinson’s Disease: Comprehensive Clinical Analysis
Objective: Aim of this study is to comprehensively compare motor and non-motor symptoms of individuals with Early Onset Parkinson's Disease (EOPD) with dopamine deficiency to…Using Multi-Generational High-Risk Pedigrees to Identify Candidate Parkinson’s Disease Predisposition Genes
Objective: To identify rare genetic variants associated with increased risk of Parkinson’s disease (PD) in multi-generational, high-risk pedigrees. Background: Our current knowledge of PD genetics…
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