Unveiling the Molecular Mechanism of Polydatin in Ameliorating Parkinson’s Disease via the DRD2/CRYAB/NF-κB Axis in Astrocytes and Exploring Cell Therapy Strategies
Objective: Define polydatin's therapeutic mechanism targeting astrocyte-mediated neuroinflammation in Parkinson's disease (PD) and assess combinatorial efficacy with dopamine progenitor transplantation. Background: PD progression involves substantia…Neural Correlates of Rhythmic Auditory Stimulation Responsiveness in Parkinson’s Disease: A Pilot Gait and fMRI Study
Objective: To compare neural activity differences between Parkinson's disease patients responsive to rhythmic auditory stimulation (RAS-r) and those not responsive (RAS-n) using functional MRI (fMRI).…Levodopa mediated normalization of cerebello-thalamo-cortical GABA and Glutamate in Parkinson’s disease
Objective: This study aims to evaluate the effect of levodopa on cerebello-thalamo-cortical (CTC) gamma-aminobutyric acid (GABA) and glutamate in patients with Parkinson’s disease (PD) using…Exploring the Association between Autonomic Responses and Dopaminergic Pathways in Early Parkinson’s Disease
Objective: To assess if cardiovascular dysautonomia, evaluated by autonomic function tests (AFTs), is related to dopaminergic nicgrostriatal loss and other non-motor symptoms in early Parkinson…Genetic Correlations Between Parkinson’s Disease and Circulating Metabolites
Objective: To use genome-wide association studies (GWASs) to identify genetic correlations between Parkinson’s disease (PD) and circulating metabolites. Background: Metabolomics is the study of small…Deep phenotyping of Parkinson‘s disease patients with the RAB32 Ser71Arg pathogenic variant and MDSGene literature review
Objective: To evaluate patients with PD and unaffected carriers of the pathogenic variant RAB32 p.Ser71Arg using a multimodal approach to gain insight into genotype-phenotype relationships…Examining the Gut Microbiome in Parkinson Patients with GBA Mutations
Objective: Gut dysbiosis is implicated in Parkinson disease (PD) pathogenesis, but less is known about the interaction of PD associated gene variants and gut microbiota.…Advancing Global Training and Capacity Building in Parkinson’s Genetics through GP2
Objective: To promote and facilitate learning by providing resources and expertise to address the training needs of the Global Parkinson’s Genetics Program (GP2; www.gp2.org) and…Rare Variants, Copy Number Variations, and Heritability Estimates in a Pilot Cohort of Egyptians with Parkinson’s Disease
Objective: To explore the genetic architecture of Parkinson's disease (PD) in Egypt, addressing the underrepresentation of this population in PD genetics research. Background: Genetic studies…Delirium following deep brain stimulation: An 8 year single-centre study
Objective: To describe the outcomes of patients undergoing deep brain stimulation (DBS) surgery for movement disorders and neuropsychiatric indications and characterise delirium symptoms. Background: Deep…
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