Effect of Exercise Intervention on Parkinson’s Disease Resting-State fMRI Functional Connectivity
Objective: Investigate the effects of exercise on resting-state (rs) fMRI functional connectivity (FC) in Parkinson’s Disease (PD). Background: Recent studies have shown strong clinical evidence…Bone Mineral Density in Early Parkinson’s Disease: Correlations with Disease Severity and Prognosis
Objective: This study aimed to evaluate the association between bone mineral density (BMD) and disease severity, progression, freezing of gait (FOG), and fracture risk in…Decreased DTI-ALPS Indices and their Association with Clinical Features in Parkinson’s Disease
Objective: To investigate possible glymphatic dysfunction using diffusion tensor image along the perivascular space (DTI-ALPS) in patients with Parkinson’s disease and their relationship with clinical…Prospective Tractography-Guided STN DBS Targeting with Optimized vmPFC Connectivity for Apathy in PD a Case Report
Objective: Prospective tractography-guided DBS targeting of the left STN-vmPFC and primary motor pathway to improve apathy alongside motor symptoms in PD. Background: While STN DBS…The regulatory variant c.–253C>T of the DNAJC13 gene as a causal factor for Parkinson’s disease in a patient with early-onset
Objective: This work aims to investigate the role of regulatory regions in Parkinson’s disease (PD) genes, which may help explain part of the missing heritability.…Interrogating GCase Activity in Human Monocytes Isolated from Parkinson’s Disease Patients Carrying the Asian LRRK2 G2385R and R1628P Variants
Objective: To compare Glucocerebrosidase-1 (GCase) activity in human monocytes of manifesting LRRK2 G2385R, R1628P, and double-variant carriers vs. idiopathic Parkinson’s disease (iPD) and healthy controls…Genetics of African Americans – Louisiana, Parkinson’s Disease – (GoAAL-PD)
Objective: Study a cohort of African American patients with PD to understand the genetic underpinnings, phenotypes, barriers to care, and engagement preferences unique to this…Asymptomatic GBA1 Mutation Carriers Have Increased Cortical Cholinergic Activity
Objective: The objective of this study was to assess cholinergic activity changes in patients with Parkinson’s disease carrying GBA1 variants(GBA-PD) and in non-manifesting carriers(GBA-NMC) using…Genetic analysis of the X chromosome and Parkinson’s disease: from the Global Parkinson’s Genetics Program
Objective: To investigate chromosome X genetic risk factors for Parkinson's disease (PD) across European ancestries (European, Ashkenazi Jewish, Finnish) using data from the Global Parkinson's…Efficacy and Safety of Fecal Microbiota Transplantation in the Management of Parkinson’s Disease: A Systematic Review
Objective: 1. Assess the efficacy of FMT in PD by evaluating its impact on motor and non-motor symptoms.2. Determine the safety profile of FMT in…
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