Exploring the Therapeutic Potential of Microglial Modulation in Parkinson’s Disease: A Study on Structural Synaptic Plasticity
Objective: We aim to explore the role of glial cells in Parkinson's disease and assess whether modulating microgliafunction could offer therapeutic benefits. Specifically, we investigate…A pathology-validated study to investigate the role of Uric Acid in Parkinson’s Disease
Objective: The aim of this study is to compare plasma uric acid levels between pathology-confirmed and clinically misdiagnosed Parkinson’s disease patients at a single-patient level.…Burden of Movements Disorders at Initiative Plus Center Hospital
Objective: describe the socio-demographic, clinical characteristics and evolutionary profiles of patients followed for movement disorders Background: The DR Congo specialists in abnormal movements are rare,…Improving awareness of motor fluctuations in Parkinson’s Disease: an educational patient support program using a waist-worn device.
Objective: To describe the utility of an educational patient support program designed to improve awareness of motor fluctuations (MF) and provide education on motor and…Utility of Serum α-synuclein Seed Amplification Assay as a Parkinson’s Disease Biomarker
Objective: To determine the sensitivity and specificity of serum α-synuclein seed amplification assay (SAA) for Parkinson’s disease (PD) diagnosis in the Systemic Synuclein Sampling Study…The Synuclein-One Study: Detection of Cutaneous Phosphorylated alpha-synuclein for the Diagnosis of the Synucleinopathies
Objective: The Synuclein-One study is an NIH-funded 30-site, multicenter trial of 428 patients with synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple…Association between changes in hippocampal volumes, cognition, and CSF markers in Parkinson’s Disease
Objective: To assess whether changes in hippocampal subfield volumes are associated with cognition or CSF β-amyloid 1–42 (Aβ42) levels in Parkinson’s Disease (PD). Background: Hippocampal…Visuo-spatial processing is linked to cortical glutamate dynamics in Parkinson’s disease – a 7 Tesla functional MRS study
Objective: To investigate alterations of glutamate metabolism in the occipital cortex during visual processing in patients with Parkinson’s disease (PD). Background: Cognitive decline is a…Management of constipation in Parkinson’s patients presenting with acute sigmoid volvulus to Royal Berkshire Hospital,Reading, UK
Objective: To evaluate management of constipation in acute sigmoid volvulus in Parkinson’s. Background: Constipation is one of the main and disabling non motor symptoms in…Plasma glucosylsphingosine in GBA1 E326K, N370S and L444P mutation carriers with and without Parkinson’s disease
Objective: To measure plasma glucosylsphingosine levels in heterozygous carriers with and without Parkinson's disease (PD) of three variants in GBA1: 1. E326K (risk factor for…
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