Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…Gait initiation in patients with Progressive Supranuclear Palsy: a biomechanical and FDG-PET study
Objective: To define the brain metabolic abnormalities related to gait initiation (GI) failure in subjects with Progressive Supranuclear Palsy (PSP). Background: PSP is an atypical…Significant hypometabolism in the posterior parietal cortex and precuneus in Parkinson’s disease with GBA mutations: [18F]FDG PET study
Objective: We explored [18F]FDG PET findings of PD patients with GBA mutation. Background: Parkinson’s disease (PD) with glucocerebrosidase (GBA) mutations is characterized by early onset…Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Subacute cognitive decline after DBS in a patient with idiopathic delayed-onset edema
Objective: To describe a patient who developed idiopathic delayed-onset edema (IDE) and cognitive decline three days after deep brain stimulation of subthalamic nucleus (STN-DBS). Background: IDE…Identifying the functional brain network of motor reserve in early Parkinson’s disease
Objective: To explore the functional brain network associated with motor reserve in early-stage Parkinson’s disease (PD). Background: The severity of motor symptoms in PD does…Microglial activation associated with a faster progression of nigrostriatal dysfunction in patients with isolated REM sleep behavior disorder
Objective: To assess the role of early microglial activation on the progression of nigrostriatal dysfunction, measured with 18F-DOPA PET, in isolated REM sleep behavior disorder…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…Visual assessment of dopamine transporter imaging in normal pressure hydrocephalus
Objective: We aimed to investigate detailed analysis for striatal dopaminergic depletion in idiopathic normal pressure hydrocephalus (iNPH) with visual assessment. Background: Variable degree of parkinsonism…
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