Brain cholinergic dysfunction in patients with isolated REM sleep behavior disorder: A clinical and 11C-Donepezil PET follow-up study
Objective: In this follow-up study, we aimed to explore the temporal changes in brain acetylcholinesterase activity and cognitive function of iRBD patients. Background: Isolated REM…Subacute cognitive decline after DBS in a patient with idiopathic delayed-onset edema
Objective: To describe a patient who developed idiopathic delayed-onset edema (IDE) and cognitive decline three days after deep brain stimulation of subthalamic nucleus (STN-DBS). Background: IDE…Identifying the functional brain network of motor reserve in early Parkinson’s disease
Objective: To explore the functional brain network associated with motor reserve in early-stage Parkinson’s disease (PD). Background: The severity of motor symptoms in PD does…Microglial activation associated with a faster progression of nigrostriatal dysfunction in patients with isolated REM sleep behavior disorder
Objective: To assess the role of early microglial activation on the progression of nigrostriatal dysfunction, measured with 18F-DOPA PET, in isolated REM sleep behavior disorder…Increased availability of the metabotropic glutamate receptor 5 in the motor system of patients with Parkinson’s disease
Objective: To investigate glutamatergic signaling in Parkinson’s disease (PD) compared to age- and gender-matched healthy controls by using 11C-ABP688-PET combined with MRI. Background: Increasing evidence…Impairment of the mesocortical dopamine system in Parkinson’s disease patients with freezing of gait in a multimodal imaging approach
Objective: To investigate the involvement of dopaminergic systems in Parkinson’s disease (PD) patients with freezing of gait (FOG) using a multimodal assessment involving 18 F-DOPA-PET…Right hemispheric β-amyloid deposition associates with freezing of gait in Parkinson’s disease
Objective: To investigate regional cerebral deposition of β-amyloid in patients with Parkinson's disease (PD) who have freezing of gait (FoG). Background: FoG is one of…Neuroimaging Extra-Striatal D2 Receptors in Parkinson’s Disease with Rapid Eye Movement Sleep Behaviour Disorder
Objective: Our aim was to characterize the extra-striatal dopamine in Parkinson’s disease (PD) with and without rapid eye movement sleep behaviour disorder (RBD) using in…[18F]THK-5351 PET Imaging in Progressive Supranuclear Palsy Concomitant with Cerebellar Ataxia in Early-stage: Clinicopathological Observations
Objective: To describe two cases of progressive supranuclear palsy (PSP) concomitant with cerebellar ataxia in early stage who underwent [18F]THK-5351 PET imaging and to investigate…Relationship between striatal dopamine depletion and various non-motor symptoms in non-demented patients with Parkinson’s disease: a pilot study
Objective: We aimed to investigate associations of striatal dopamine uptake and various non-motor symptoms in non-demented patients with Parkinson’s disease (PD). Background: Dopamine transporter (DAT)…
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