Multiple System Atrophy: phenotypic spectrum approach coupled with brain FDG PET
Objective: This study attempts to identify different phenotypes of patients with MSA and to describe corresponding brain 18-FDG Positron Emission Tomography (PET) patterns. Background: In…Imaging Brain Insulin Resistance in Parkinson’s Disease using [¹⁸F]FDG-PET
Objective: To obtain a glucose brain uptake survey of Parkinson's Disease (PD) patients with or without insulin resistance (IR). Background: IR is common in PD…Potential involvement of the caudate nucleus in GBA-associated Parkinson’s disease
Objective: Multimodal functional assessment of striatocortical loop integrity in Parkinson’s Disease (PD) patients with and without GBA variants Background: Biallelic GBA mutations provoke the lysosomal…Beneficial effect of estrogen on nigrostriatal dopaminergic neurons in drug-naïve postmenopausal Parkinson’s disease
Objective: To investigate the potential beneficial effects of estrogen on nigrostriatal dopaminergic neuron degeneration in postmenopausal drug-naïve Parkinson’s disease. Background: Epidemiologic studies have revealed that…“Brain-first” vs. “body-first” Parkinson’s disease is determined by RBD-status – a multi-modality imaging study
Objective: In a multi-modality imaging study, we test the hypothesis that Parkinson’s disease (PD) can be divided into two strikingly distinct phenotypes: (1) PD patients,…Genotype influences circuit compensation in Parkinson’s disease
Objective: This study investigates differences in brain network organization in patients with Parkinson’s disease (PD) with genetic risk factors relative to sporadic PD patients and…Cortical FDG-PET patterns predict long-term motor progression and disability milestones in Parkinson’s disease
Objective: To evaluate the accuracy of single-subject FDG-PET in predicting motor and cognitive long-term progression in Parkinson's disease Background: The progression of Parkinson's disease is…Visual assessment of dopamine transporter imaging in normal pressure hydrocephalus
Objective: We aimed to investigate detailed analysis for striatal dopaminergic depletion in idiopathic normal pressure hydrocephalus (iNPH) with visual assessment. Background: Variable degree of parkinsonism…Cortical cholinergic dysfunction correlates with microglial activation in the Substantia Innominata in patients with REM sleep behavior disorder
Objective: To explore possible correlations between levels of microglial activation (neuroinflammation) in the Substantia Innominata (SI), the major source of cholinergic input to the cortex,…Abnormal metabolic brain network in multiple system atrophy and progressive supranuclear palsy: a replication on a new European cohort
Objective: To identify characteristic metabolic brain patterns specific for multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a new cohort of patients and…
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