Imaging correlates of impaired self-awareness of cognitive deficits in Parkinson’s disease
Objective: To discover the neural basis of impaired self-awareness of cognitive deficits (ISA-cog) in Parkinson’s disease (PD) patients with mild cognitive impairment (MCI). Background: Anosognosia…The Dutch Parkinson and Cognition study (DUPARC): Cognitive impairment and cholinergic innervation in de novo Parkinson’s Disease patients
Objective: To explore the incidence and characteristics of early cognitive impairment in Parkinson’s disease (PD) patients and the relationship with regional cholinergic innervation. Background: Cognitive…Brain amyloid contribution to cognitive dysfunction in Lewy bodies disorders: a pilot study
Objective: To investigate regional [18F]florbetapir binding to amyloid-β and its contribution to cognitive dysfunction in Lewy bodies disorders. Background: Lewy bodies disorders like Parkinson’s disease…Molecular correlates of survival and clinical severity in Progressive Supranuclear Palsy
Objective: To test how regional tau pathology and neuroinflammation are associated with clinical severity and survival in progressive supranuclear palsy (PSP). Background: The abnormal aggregation…Evaluation of Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s Disease: An in vivo [11C]BU99008 PET study
Objective: We aimed to evaluate the role of astroglia activation in Parkinson's disease (PD) using [11C]BU99008 PET, a novel radioligand with high specificity and selectivity…Presynaptic dopamine depletion determines the timing of levodopa-induced dyskinesia onset in Parkinson’s disease
Objective: To investigated whether dopaminergic function in the nigrostriatal system is associated with the timing of levodopa-induced dyskinesia (LID) onset in Parkinson's disease (PD). Background:…Amyloid PET and cognition in Parkinson’s disease
Objective: To investigate the relationship between cerebral amyloid accumulation and cognition in Parkinson’s disease (PD). Background: The neuropathology underlying the development of dementia in Parkinson’s…Comparisons of cerebral glucose metabolism and striatal DAT binding in PD patients with and without RBD
Objective: This study aims to identify the differences of functional neuroimaging phenotype between Parkinson’s disease (PD) patients with REM sleep behavior disorder (RBD) (PD+RBD+) and…In vivo staging of pathology in REM sleep behaviour disorder
Objective: To study the level of dysfunction in the peripheral and central nervous system in idiopathic REM sleep behaviour disorder (iRBD) patients. Background: α-synuclein (α-syn)…Automated Differential Diagnosis of Parkinsonian Syndromes Using FDG-PET Metabolic Brain Network Analysis
Objective: To discriminate among parkinsonian patients using an automated network analysis of FDG-PET brain images. Background: Clinical differentiating among parkinsonian syndromes: Parkinson’s disease (PD), multiple…
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