Behavior and PET Imaging Study in Parkinsonian Rat Models Induced by Injection of 6-OHDA in Medial Forebrain Bundle
Objective: To employ behavioral test, positron emission tomography (PET) imaging and immunohistochemical staining to assess the changes of brain function and dopaminergic system in rat…A Study on Combined Brain Positron Emission Tomography (PET) – Magnetic Resonance Imaging (MRI) Using Fluorodeoxyglucose (18FDG) (FDG-PET/MRI) in Premanifest Huntington’s Disease Gene-expansion Carriers
Objective: By a combined brain PET–MRI using FDG, we wished to simultaneously characterize the structural and metabolic brain changes in premanifest HD gene-expansion carriers. Background:…Hypometabolism of the posterior parietal cortex in PD with dementia: [18F]FDG PET study
Objective: To investigate the neuroimaging marker for dementia in Parkinson’s disease (PD) patients using [18F]FDG PET. Background: Dementia may occur in patients with PD during…Evaluation of motor impulsivity in Huntington Disease with a choice reaction time task and brain metabolic (PET 18FDG) imaging
Objective: To describe motor impulsivity in early Huntington disease (HD) with electromyographic (EMG) recordings during a choice reaction time task (Simon Task) and brain metabolic…A longitudinal PET study to assess progression of laterality in Parkinson’s disease
Objective: This study aims to identify in Parkinson’s disease (PD) whether striatal dopamine transporter (DAT) losses occur at a similar rate in both sides of…[18F]FP-CIT and [18F]FDG PET findings in MSA patients with cognitive impairment
Objective: We investigated the brain dopaminergic system and glucose metabolism in multiple system atrophy (MSA) patients with cognitive impairment. Background: Since the first report of…Study on feasibility to develop a central nervous system (CNS) Leucine-rich repeat kinase 2 (LRRK2) PET tracer
Objective: To assess feasibility of developing a CNS LRRK2 PET tracer. Background: LRRK2 enzyme belongs to the leucine-rich repeat kinase family. Pathogenic mutations in the…18F-FDG PET brain in Parkinsonism
Objective: To determine if 18F-FDG PET can differentiate Parkinson's Disease from Parkinson's-Plus syndromes Background: Parkinsonism is a clinical syndrome of tremor, rigidity, bradykinesia and postural…Alterations of cortical metabotropic glutamate receptor-mediated signaling in patients with Parkinson’s disease
Objective: To evaluate expression of brain metabotropic glutamatergic receptor 5 and the relationship with clinical measures in Parkinson’s disease patients. Background: Metabotropic glutamate receptor 5…Amyloid deposition affects cognitive manifestations in Parkinson’s disease: The PPMI dataset
Objective: To investigate the contribution of amyloid depositions to cognitive deficits in the early phase of Parkinson’s disease (PD). Background: Involvement of amyloid deposits is…
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