Extrapyramidal involvement in amyotrophic lateral sclerosis: results of a prospective population-based study
Objective: To assess frequency, clinical characteristics and functional neuroimaging correlates of parkinsonian signs in a population-based series of new-diagnosed amyotrophic lateral sclerosis (ALS) patients. Background:…[18F]-AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP
Objective: This study was designed to investigate the binding of [18F]-AV-1451 to neuromelanin in parkinsonisms. Uptake in the substantia nigra of Parkinson’s disease (PD) and…Assessing cholinergic innervation in Parkinson’s disease using the PET imaging marker [18F]Fluoroethoxybenzovesamicol
Objective: To validate [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) imaging in healthy volunteers by dynamic scanning. The secondary objective of this study was to evaluate the differences in [18F]FEOBV binding…PET-MRI Imaging in Parkinson Dementia Complex of Guam: A Case Report
Objective: To describe the PET-MRI brain and DaTscan findings in a case of Parkinson Dementia Complex of Guam. Background: The indigenous Chamorro people of Guam…Hypometabolism in Orbitofrontal and Perirhinal Cortex is Associated with Impulse Control Disorder in Parkinson´s Disease
Objective: (i)To elucidate the metabolic correlates sub-serving the clinical expression of ICD in PD and (ii) to evaluate the association between the glucose metabolism and…Altered PDE10A Expression Detectable Early in Untreated Parkinson’s Disease Patients
Objective: To investigate in vivo whether loss of PDE10A expression in Parkinson’s disease (PD) is an early phenomenon in early untreated PD patients using positron…Imaging of phosphodiesterase 10 A (PDE10A) enzyme levels in the living human brain of Huntington’s disease gene expansion carriers and healthy controls with positron emission tomography.
Objective: The objective of this study was to examine the loss of Phosphodiesterase 10A enzyme (PDE10A) across a broad spectrum of Huntington’s disease (HD) stages.…F-18-DOPA-PET predicts impulsive behavior under dopaminergic therapy in Parkinson patients
Objective: The aim of this study is to investigate the influence of the intensity of dopaminergic projections to the ventral striatum (VS) measured with F-18-DOPA-PET…Clinical characteristics of cognitive impairment in patients with Parkinson’s disease and its related pattern in 18F-FDG PET imaging
Objective: To characterize the clinical features and the neuroanatomical bases of cognitive impairment in Parkinson’s disease (PD) with respect to attention, executive function, memory, language,…Phosphodiesterases and striatal pathways in Parkinson’s disease
Objective: To use phosphodiesterase (PDE)10A ([11C]IMA107) and PDE4 ([11C]Rolipram) positron emission tomography (PET) molecular imaging combined with diffusion tensor imaging (DTI) based probabilistic tractography to explore the expression…
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