MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Progressive supranuclear palsy(PSP)"

  • 2025 International Congress

    Neuroinflammatory response is determined by HLA genotype in progressive supranuclear palsy

    G. Kovacs, H. Chasiotis, S. Zaheer, J. Wang, J. Li, MC. Tartaglia, S. Fox, A. Lang, S. Forrest (Toronto, Canada)

    Objective: Our aim was to examine whether the HLA haplotypes influence the neuroinflammatory response in a cohort of neuropathologically diagnosed PSP cases. Background: Progressive supranuclear…
  • 2025 International Congress

    Noradrenaline treatment of apathy and impulsivity in participants with Progressive Supranuclear Palsy syndromes (NORAPS)

    R. Durcan, H. Paula, D. Street, A. Murley, S. Jones, A. Church, C. Kobylecki, V. Marshall, C. Antoniades, B. Ghosh, J. Rowe (Cambridge, United Kingdom)

    Objective: The NORAPS phase II study (ISRCTN99462035) investigates the safety, tolerability and efficacy of atomoxetine in Progressive Supranuclear Palsy (PSP). Background: PSP is a neurodegenerative…
  • 2025 International Congress

    Validation of the Short Progressive Supranuclear Palsy Quality of Life Scale in PSPNI

    Q. Shen, XY. Li, J. Wang, FT. Liu (Shanghai, China)

    Objective: This study aimed to evaluate the reliability, validity, and sensitivity to change of the PSP-ShoQoL in PSPNI, a longitudinal Chinese PSP cohort. Background: Self-reported…
  • 2025 International Congress

    Quantitative Regional Tau Pathology and Spatial Transcriptomics Identify Signatures of Phenotypic Diversity in Progressive Supranuclear Palsy.

    P. Cullinane, J. Parmera, T. Curless, L. Paras Chajed, S. Wrigley, W. Sifontes Valladares, J. Anton Arnal, M. Burrows, K. Ebanks, M. Blunskyte, D. Gavriouchkina, L. Binding, T. Revesz, S. Brandner, A. Young, E. de Pablo-Fernández, H. Morris, Y. Lim, H. Nelvagal, T. Warner, Z. Jaunmuktane (London, United Kingdom)

    Objective: To determine the pathological and molecular determinants of phenotypic diversity in PSP. Background: PSP exhibits broad variability in clinical phenotype and progression, however the…
  • 2025 International Congress

    Utilizing the 15-item modification of the PSPRS rating scale (mPSPRS-15) as the primary endpoint for future clinical trials in progressive supranuclear palsy

    F. Nery, T. Nevmyrych, J. Murphy, S. Wu, Y. Zabar, A. Gafson, S. Bullain, J. O’Gorman (Cambridge, USA)

    Objective: To compare the properties of PSPRS-28, mPSPRS-15, and the rPSPRS-10 and assess their utility as a primary endpoint in PSP trials. Background: Progressive supranuclear…
  • 2025 International Congress

    Concomitant Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis Versus Motoneuron Phenotype of PSP in Ukrainian Patient

    Y. Trufanov, Y. Compta, M. Trishchynska, N. Khanenko, G. Chupryna, V. Sereda, A. Ovchynnykova (Kyiv, Ukraine)

    Objective: To provide a description of a rare case of mixed progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) in Ukrainian patient. Background: The…
  • 2025 International Congress

    Brain Cholinergic Changes in Progressive supranuclear palsy: A single-subject voxel-wise approach to understanding heterogeneity

    P. Kanel, G. Carli, J. Barr, R. Vangel, A. Narkis, C. Spears, P. Scott, R. Albin, N. Bohnen (Ann. Arbor, USA)

    Objective: To characterize individual-level topographical patterns of cholinergic changes compared to controls in Progressive Supranuclear Palsy (PSP) using a voxel-wise approach. Background: The cholinergic system…
  • 2025 International Congress

    The IMPACT study: protocol of a randomised controlled single-blind trial evaluating efficacy and cost-effectiveness of telenursing in atypical parkinsonism

    R. Cilia, V. Leta, F. Colucci, A. Suppa, F. Valentino, C. Terranova, C. Leuzzi, J. Cordasco, G. Fusi, S. Floridia, F. de Giorgi, R. Telese, A. Braccia, A. Zampogna, G. Pinola, M. Patera, G. Belluscio, S. Crivellari, E. Antoniazzi, S. Cascino, A. Giaco, A. Masaracchio, G. Moreschi, M. Catotti, R. Eleopra (Milan, Italy)

    Objective: To present the protocol of a study evaluating the efficacy and cost-effectiveness of a 12-month integrated program aimed at improving healthcare delivery and coordinated…
  • 2025 International Congress

    Balance confidence may not accurately assess fall risk in atypical parkinsonism

    G. Arleth, E. Buxton, R. Bryant, M. Ivancic, N. Browner, J. Shurer, M. Sklerov (Chapel Hill, USA)

    Objective: Objective: To examine if balance confidence, measured by the Activities-specific Balance Confidence (ABC) scale, reflects fall frequency in atypical parkinsonian syndromes (APS), namely multiple…
  • 2025 International Congress

    White Matter Abnormalities in Progressive Supranuclear Palsy (PSP) vs. Parkinson’s Disease (PD): Evaluation with a Convolutional Neural Network (CNN)-Based Tool

    S. Zaheer, Y. Patel, M. Abarghouei Emamikhah, N. Bendahan, R. Zou, M. Malik, N. Owsicki, N. Paul, Q. Nguyen Victor, A. Boutet, A. Lang (Toronto, Canada)

    Objective: This study aimed to compare white matter hyperintensity (WMH) burden between PSP and PD using a novel AI-based tool for more accurate WMH volume…
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