Rapid Cognitive Deterioration and Related Factors in Progressive Supranuclear Palsy: a One-Year Follow-up Study
Objective: Based on a relatively large cohort, we aimed to show the switch of cognitive status in patients with progressive supranuclear palsy (PSP) after one-year follow-up…Regional tau burden patterns and their associations with clinical severity in progressive supranuclear palsy (PSP)-Richardson’s syndrome and PSP- predominant parkinsonism: a prospective cohort study
Objective: To explore whether PSP-RS) and PSP-P have different regional tau burden distributions in the brain and whether these distributions are related to motor and…PSP-Like Syndrome Associated with Dysautonomic Findings as a Presentation of an Anti-Iglon5 Antibody-Related Encephalopathy
Objective: Report a case of a PSP-like syndrome associated with dysautonomic findings as a presentation of an anti-IgLON5 antibody-related encephalopathy. Background: Antibodies against immunoglobulin-like cell…Longitudinal progress and clinical relevance of 18F-Florzolutau PET in patients with PSP: a one-year follow-up study
Objective: Here we aimed to explore the progress of 18F-Florzolotau PET and its clinical relevance in patients with PSP during one-year follow-up. Background: The 18F-Florzolotau…Metabolic Progressive Subtypes in Progressive Supranuclear Palsy
Objective: To investigate disease-specific spatiotemporal progression in Progressive supranuclear palsy (PSP) patients using 18F-fluorodeoxyglucose (FDG) PET and the Subtype and Stage Inference (SuStaIn) algorithm, to…The Impact of Apathy and Impulsivity on Caregivers in Atypical Parkinsonian Syndromes
Objective: This study aims to investigate the impact of apathy and impulsivity on the quality of life and burden for carergivers of people with Atypical…Nigral Neuroinflammation and Dopaminergic Neurons in PD, MSA and PSP: A Comparative Clinicopathological Study
Objective: To investigate nigral neuroinflammatory markers and dopaminergic neuron counts in parkinsonian disorders, comparing their profiles across conditions. Background: In degenerative parkinsonian disorders, the primary…Decoding non-IPD Parkinsonism – A Comparative Analysis of Atypical and Secondary Parkinsonism
Objective: Using precise diagnostic criteria, the single-center observational study aims to evaluate the clinical profiles of non-IPD parkinsonism, specifically identifying crucial clinical clues for discriminating…ORION: A Global Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of AMX0035 in Progressive Supranuclear Palsy (A35-009)
Objective: Here we describe ORION, a phase 3 trial assessing efficacy and safety of AMX0035 in progressive supranuclear palsy (PSP). Background: PSP is a rare,…Clinical and neuroimaging factors associated with survival in Progressive Supranuclear Palsy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Progressive Supranuclear Palsy (PSP)…
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