Association between Kinetic Parameters of Alpha-synuclein Seed Amplification Assay in CSF and Parkinson’s Disease Subtypes.
Objective: To assess differences in kinetics parameters of the αSyn seeding amplification assays in CSF (CSF-αSyn-SAA) in Parkinson’s Disease (PD) subtypes based on the presence…Subjective Cognitive Decline in a National Population-based probable RBD Survey
Objective: Examine the prevalence of Subjective Cognitive Decline (SCD) in a national population-based survey among participants at risk for RBD Background: SCD is defined as…Impairment of REM Sleep Architecture: A Potential Biomarker for Parkinson’s Progression
Objective: Our study finds that the effects of Parkinson’s disease on impairing normal REM sleep far surpass those of the RBD subpopulation alone. In fact,…The effect of comorbid chronic post-traumatic stress disorder in dream enactment behavior among veterans with Parkinson’s disease and REM sleep behavior disorder
Objective: 1. To determine the co-occurrence rate of PTSD in veterans with PD and RBD.2. To evaluate severity of dream enactment behavior (DEB) and rate…Sympathetic Nervous System Overactivity in the Pre-Motor Stage of Parkinson’s Disease: Therapeutic Implications
Objective: To investigate sympathetic nervous system (SNS) activity in idiopathic REM behavior disorder (iRBD) subjects at risk for Parkinson's disease (PD), and the effect of…Rationale and Design of the Slowing Parkinson’s Early through Exercise Dosage – United Kingdom (Slow-SPEED-UK) Trial
Objective: Slow-SPEED-UK is a randomized controlled trial investigating the effects of an app-based exercise program on individuals at higher risk of Parkinson’s Disease (PD). Background:…Slow-SPEED-NL: study protocol for a remote trial of exercise for Parkinson’s disease prevention
Objective: To determine the feasibility and preliminary efficacy of a remote exercise intervention in prodromal Parkinson’s disease (PD). Background: Disease-slowing interventions have been ineffective in…Cortical and Subcortical Brain Volume Changes in Idiopathic REM Sleep Disorder Subjects at Risk for Parkinson’s Disease
Objective: To quantify cortical and subcortical brain volumes using structural MRI analysis in idiopathic REM sleep behavior disorder (iRBD) subjects at risk for Parkinson`s disease…Pure Autonomic Failure As a Severe “Body-First Subtype” of Lewy Body Disease: A Multimodal Imaging Study of the Autonomic Nervous System
Objective: Using multi-modal imaging this study aimed to characterize the deterioration of the parasympathetic and sympathetic nervous system in pure autonomic failure (PAF) in comparison…Identification of Brain Atrophy Subtypes in Prodromal and Overt Synucleinopathies: A Multicenter Study
Objective: To identify unique subtypes of synucleinopathy with distinct spatiotemporal patterns and trajectories of brain atrophy and disease burden. Background: The synucleinopathies manifest as a…
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