Translation of a subject-specific stereotaxic platform to a large animal deep brain stimulation research models
Objective: To evaluate the feasibility and accuracy of applying the commercially-available, FHC STarFix platform system for direct targeting of deep brain stimulation electrodes in a…A Pilot Study of Gamma Knife Radiosurgery Targeting the Subthalamic Nucleus in Elderly and Infirmed Parkinson’s Disease Patients Not Amenable to Deep Brain Stimulation
Objective: To evaluate the safety and efficacy of unilateral subthalamic nucleus (STN) gamma knife surgery (GKS) in patients with Parkinson’s disease (PD) not amenable to…Stereotactic Lesioning of Nucleus Accumbens for Treatment of Aggression in Mental Retardation
Objective: To present and discuss a case of stereotactic ablation of bilateral nucleus accumbens (NAc) in a mentally retarded patient to alleviate symptoms of severe aggression.…Effect of Post-Operative Symptomatic Lead Edema Associated with Subthalamic Deep Brain Stimulation On Clinical Outcomes
Objective: To assess whether development of post-operative symptomatic edema around deep brain stimulation (DBS) leads impacts clinical outcomes. Background: Post-operative symptomatic delayed edema around the…Controlled neural organoids grafting promotes functional recovery in experimental parkinsonism
Objective: We propose that the striatal transplantation of 3D-neural organoids of controlled cell size and cell content, named "Controlled Neural Organoids" (CNOs), could circumvent the…Blinded acute assessment of electrode contact efficacy compared with contact location for Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease
Objective: This study aimed to assess the clinical efficacy of each contact and the correlation between the clinical best contacts and radiologically defined optimal contacts.…Modified Frameless Stereotaxy for Gene Therapy in Pediatric Movement Disorder Patients
Objective: We have developed a modified frameless stereotaxic system for viral vector delivery of gene therapy in pediatric movement disorder patients with congenital enzyme deficiency.…Biofabricated tissue constructs to recapitulate the anatomy and functionality of the nigrostriatal pathway in Parkinson’s disease
Objective: 1) Biofabricate constructs that mimic the cytoarchitecture and function of the nigrostriatal pathway, and 2) Microinject constructs to assess restoration of dopaminergic input to…Gamma Knife Radiosurgery for Generalised Dystonia: Is It The Last Part in The Ship of Theseus
Objective: To evaluate the role of radiosurgical thalamotomy in cases of medically refractory generalised dystonia in current era. Background: Gamma knife radiosurgery has been proved…Gamma Knife Radiosurgery for essential and parkinsonian tremor: Long-term experience in a Spanish center
Objective: To describe the experience of a single Spanish center in gamma knife thalamotomy (GKT) as treatment of refractory tremor in patients with Essential Tremor…
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