MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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Articles tagged "Substantia nigra"

  • 2025 International Congress

    Predictors of Clinical Benefit from Adaptive DBS Compared to Conventional DBS in Parkinson’s Disease

    J. Tanimura, T. Hashimoto (Matsumoto, Japan)

    Objective: To identify patient characteristics predicting adaptive deep brain stimulation (aDBS) superiority over conventional DBS (cDBS) in Parkinson's disease (PD). Background: Adaptive DBS, modulated in…
  • 2025 International Congress

    Modeling Levodopa Resistance in Parkinson’s Disease: A Novel Approach Targeting Locus Coeruleus Degeneration

    A. Goel, R. Goel (Bathinda, India)

    Objective: To develop a Parkinson’s disease (PD) model replicating levodopa (LD) resistance by incorporating degeneration of both the substantia nigra (SN) and locus coeruleus (LC),…
  • 2025 International Congress

    Profiling Neural Protein Dopaminylation in Parkinson’s disease

    W. Chen, I. Maze (NEW YORK, USA)

    Objective: The hallmark of Parkinson’s Disease is motor dysfunction from the decline in dopaminergic cells in the substantia nigra (SN), leading to the development of…
  • 2025 International Congress

    Transcranial sonography in Parkinson’s disease patients

    D. Khasanova, I. Khasanov, Z. Zalyalova (Kazan, Russian Federation)

    Objective: To present the usage and results of transcranial sonography (TCS) in Parkinson's disease (PD) patients. Background: (TCS) has emerged as a valuable diagnostic tool…
  • 2025 International Congress

    Histopathology of long-term implants of peripheral nerve tissue into the substantia nigra of patients with Parkinson’s disease

    J. Quintero, A. Marlonsson, A. Granholm, G. Gerhardt, C. van Horne (Lexington, USA)

    Objective: To characterize autologous peripheral nerve tissue (PNT) implants into the substantia nigra of individuals with PD who participated in our previous clinical trials. Background:…
  • 2024 International Congress

    Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI

    K. Poston, J. Ha, T. Montine, S. Bukhari, T. Foroud, L. Heathers, K. Nudelman, I. Aldecoa, A. Garrido, J. Franz, C. Stadelmann, J-P. Vonsattel, A. Siderowf, L. Chahine, T. Simuni, K. Marek (Stanford, USA)

    Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…
  • 2024 International Congress

    TM9SF2 Knockdown Decreases Pathological Alpha-synuclein Aggregation In Vivo

    C. Sortwell, R. Kumaran, F. Manfredsson, C. Kemp, M. Benskey, J. Patterson, A. Stoll, J. Howe, N. Kuhn, K. Luk, M. Cookson (Grand Rapids, USA)

    Objective: To determine whether knockdown of transmembrane 9 super family 2 (TM9SF2) decreases the formation of alpha-synuclein inclusions and toxicity to nigral neurons in the…
  • 2024 International Congress

    Ultrasonography Markers in Prodromal Parkinson’s Disease

    S. Secades Garcia, J. Perez, B. La Casa, A. Contreras, F. Grandas (MADRID, Spain)

    Objective: This study aims to investigate ultrasonography markers  as a potential imaging marker in prodromal Parkinson's disease, with the goal of identifying individuals at higher…
  • 2024 International Congress

    Ionic Plasticity of Midbrain GABAergic Synapses in PD Models

    A. Borgkvist, E. Bezard, M. Molinari, E. Santini, M. Canron (Solna, Sweden)

    Objective: To validate that enhancing potassium-chloride cotransporter activity would restore inhibition and normal function in parkinsonian Substantia nigra reticulata (SNr) and participate to Parkinson’s disease (PD) symptom alleviation. Background: The SNr is an output nucleus…
  • 2023 International Congress

    An Interesting Case of COVID-19 related Parkinsonism

    P. Bhatia, A. Ata, K. Bailey (Tampa, USA)

    Objective: Virus related Parkinsonism causing encephalitis lethargica has been documented in the literature. The novel Coronavirus (COVID-19) has been linked to a small number of…
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