Concordance of Neuropathologic Diagnosis of Lewy Body Disease with Baseline Alpha-Synuclein Seed Amplification Assay in PPMI
Objective: To determine whether the alpha-synuclein seed amplification assay (aSyn-SAA) performed on cerebral spinal fluid (CSF) collected at the baseline (BL) PPMI visit is concordant…TM9SF2 Knockdown Decreases Pathological Alpha-synuclein Aggregation In Vivo
Objective: To determine whether knockdown of transmembrane 9 super family 2 (TM9SF2) decreases the formation of alpha-synuclein inclusions and toxicity to nigral neurons in the…Ultrasonography Markers in Prodromal Parkinson’s Disease
Objective: This study aims to investigate ultrasonography markers as a potential imaging marker in prodromal Parkinson's disease, with the goal of identifying individuals at higher…Ionic Plasticity of Midbrain GABAergic Synapses in PD Models
Objective: To validate that enhancing potassium-chloride cotransporter activity would restore inhibition and normal function in parkinsonian Substantia nigra reticulata (SNr) and participate to Parkinson’s disease (PD) symptom alleviation. Background: The SNr is an output nucleus…An Interesting Case of COVID-19 related Parkinsonism
Objective: Virus related Parkinsonism causing encephalitis lethargica has been documented in the literature. The novel Coronavirus (COVID-19) has been linked to a small number of…The neuroprotective properties of NLX-112 in MPTP treated mice are mediated by reactive gliosis and astrocytic GDNF
Objective: To investigate whether NLX-112, a potent and selective 5-HT1A agonist is neuroprotective in a mouse MPTP model of Parkinson’s Disease (PD) [1]. Background: There…Diagnosis of Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy with 7T-MRI substantia nigra imaging
Objective: To detect the signal change of nigrosome-1 in 7T-MRI and its diagnostic and differential diagnostic efficacy as the imaging biomarker of PD, MSA-P, MSA-C…Case report- Cavernoma involving substantia nigra and nigrostriatal pathway as a rare cause of secondary parkinsonism with a 3 year follow up
Objective: To describe a case report of a rare cause of Parkinsonism Background: Vascular malformations such as cerebral cavernomas are known to predispose to haemorrhagic…An in-vivo study of the integrity of the nigrostriatal pathways in drug-naive Parkinson’s disease patients using [11C]PE2I PET and neuromelanin-Magnetic Resonance Imaging
Objective: This study evaluated the relationship between the neurodegeneration of the substantia nigra neurons, assessed using Neuromelanin-sensitive MRI, and of the loss of striatal dopaminergic…Agreement between swallow tail sign asymmetry and clinical laterality in Parkinson’s disease
Objective: Our goal was to evaluate the concordance between asymmetry in nigral hyperintensity detected with 3T MRI and clinical symptomatology. Background: A promising MRI marker…
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