SAFE-DBS – A monocentric, randomised, blind evaluation of safinamide in the perioperative period in Parkinsonian patients with deep brain stimulation
Objective: This monocentric, randomised, blind study is designed to evaluate the effect of safinamide on motor and neuropsychiatric symptoms in the 3 month perioperative period…Characteristics of cases in which stimulation was programmed for multiple targets in deep brain stimulation therapy for Parkinson’s disease.
Objective: To clarify the the clinical background of Parkinson's disease patients with DBS who received multiple stimulus targets. Background: Deep brain stimulation (DBS) is an…Predicting motor outcome and quality of life after subthalamic DBS for Parkinson’s Disease: the role of standard screening measures and wearable-data
Objective: To evaluate the utility of universal components incorporated in the DBS screening, complemented by a wearable sensor, to predict motor outcomes and Quality of…local field potential differences in stn subregion during performance of a conflict task in humans with parkinson’s disease
Objective: Examine dorsal and ventral STN subregion's roles in motor conflict with intraoperative recordings during the implantation of a DBS device in Parkinson’s disease (PD)…Moving beyond trial and error: a strategy for anatomically informed contact selection in subthalamic deep brain stimulation for Parkinson’s disease.
Objective: In this study we aimed to investigate and compare the utility of conventional DBS programming strategies and anatomically informed approaches predicting long term motor…APOE-ɛ4 status and cognitive decline after subthalamic nucleus-deep brain stimulation in Parkinson’s disease: preliminary results of the GENEPARK-DBS study
Objective: The aim of this study was to evaluate wheter the presence of APOE-ε4 in a cohort of Parkinson’s disease (PD) patients treated with subthalamic…Theoretical Definition of DBS Electrode Misplacement
Objective: To propose a definition of Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) electrode misplacement (MP) based on ideal brain connectivity strength. Background: MP is defined…Deep brain stimulation impacts functional brain connectivity in Parkinson’s disease.
Objective: Deep-brain stimulation (DBS) became a successful method to treat Parkinson’s disease (PD), particularly with stimulating the subthalamic nucleus (STN-DBS), although the precise mechanisms mediating…Tremor characteristics differentially respond to levodopa and subthalamic nucleus deep brain stimulation in Parkinson’s disease
Objective: To identify factors predictive of responsiveness of tremor to levodopa and STN-DBS. Background: Tremor in Parkinson’s disease (PD) is phenotypically variable and has an…Directional deep brain stimulation therapy in the long term
Objective: To describe our long-term clinical experience with directional deep brain stimulation (d-DBS) in patients with advanced Parkinson’s disease (PD) who have been implanted with…
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