Increased lysosphingolipids levels in blood of patients with multiple system atrophy
Objective: To estimate activity of lysosomal enzymes and lysosphingolipids concentration in dry blood spot of patients with synuleinopathies: Parkinson’s disease (PD), dementia with Lewy bodies…Shaking Palsy of the Larynx – a Potential Biomarker for Multiple System Atrophy
Objective: To define a clinical biomarker that allows for early identification of Multiple System Atrophy. Background: In its early stages MSA can be difficult to…Analysis of brain-derived blood exosomes for diagnostics of synucleinopathies
Objective: Here, we aimed to determine if measuring of α-synuclein concentration in these vesicles from oligodendrocytes and neurons can distinguish between patients with MSA or…Motor-based assessment of prodromal Parkinson’s disease combining wearable sensors and machine learning
Objective: To provide the neurologist with a decision support system based on inertial sensors and learning algorithms for an objective early diagnosis of Parkinson’s disease…Extracellular α-synuclein enters dopaminergic neurons by modulating flotillin-1-assisted DAT endocytosis
Objective: In this study, we examine the regulatory role of flotillin-1 in dopamine transporter (DAT) trafficking and the impact of extracellular α-synuclein (αS) on this…Alpha-synuclein interacts with BAF complex in nucleus
Objective: This study aims to uncover the prospective partner of αS in nucleus. Background: In neuronal cells, large part of alpha-synuclein (αS) localize at presynaptic…Self-reported demographic, genetic, symptom, and treatment data of subjects in the Fox Trial Finder
Objective: To examine the characteristics of subjects within the Fox Trial Finder (FTF) database. Background: FTF is an online, patient driven database by which Parkinson’s…Applicability of questionnaires and study of the prevalence of REM Sleep Behavior Disorder (RBD) in Parkinson’s disease
Objective: Evaluation of patients with idiopathic Parkinson's disease regarding the presence of RBD, application of the questionnaires, and correlation between the diagnosis of RBD by…Amplification of α-synuclein aggregates in cerebrospinal fluid by rapid ultrasonication-based assay
Objective: To apply an ultrasonication-based misfolded protein amplification to the evaluation of α-synuclein aggregates in CSF, and to investigate their clinical significances in Parkinson’s disease…Arterial spin labelling detects subcortical hypoperfusion in early drug-naïve patients with Parkinson’s disease
Objective: We evaluated regional cerebral blood flow (CBF) levels in a cohort of early drug-naïve patients with Parkinson’s disease, and we explored for associations between…
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