Peripheral Synucleinopathy in Essential Tremor Plus Patients with Parkinsonian Features and Normal Dopamine Transporter Imaging
Objective: To describe results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) in patients with essential tremor (ET) with parkinsonism. Background: Patients with longstanding ET may…In vivo proteomic investigation of deeply phenotyped parkinsonian syndromes for biomarkers of differential diagnosis
Objective: To investigate deeply-phenotyped cohorts of parkinsonian syndromes using proteomic technologies for identification of biomarkers for differential diagnosis Background: Proteomic technologies like Olink® Explore 3072…Widespread Synuclein pathology in hyposmics precedes dopamine transporter deficit in PARS
Objective: The Parkinson Associated Risk syndrome (PARS) study is designed to identify a Parkinson disease (PD) biomarker/clinical marker derived cohort enriched to develop typical symptoms…Clinico-pathological correlations in atypical parkinsonism
Objective: We aim to assess diagnostic accuracy of the Parkinson-plus syndromes (PPS) using the current consensus criteria, whilst identifying the diagnostically most salient clinical features.…Combined GWAS of Dementia with Lewy Bodies, REM-Sleep Behavior Disorder, Parkinson’s Disease and Alzheimer’s Disease
Objective: To identify genetic variants that are either shared between or specific for Dementia with Lewy Bodies (DLB), REM Behavior Disorder (RBD), Parkinson’s disease (PD)…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…Remote keyboard tapping: potential signatures of early motor dysfunction in isolated REM sleep behaviour disorder
Objective: To compare keyboard tapping performance in people with iRBD with controls. Background: The Distal Finger Tapping (DFT)1 test and BRadykineisa Akinesia Incoordination test (BRAIN)2…Differential proteomic analysis of plasma exosomes in Parkinson disease associated with mutations in the GBA gene
Objective: To identify the protein changes and to search the potential biomarkers of PD among GBA mutation carriers. Background: Mutations in the GBA gene encoding glucocerebrosidase enzyme are the…Intestinal microbial dysbiosis promotes prebiotic-reversible inflammation in Parkinson’s disease
Objective: To determine the functional effects of disrupted intestinal microbiota in Parkinson’s disease (PD), particularly the impacts of dysbiosis on inflammation, neuroprotective hormone secretion, and…Prevalence and distribution of disease-associated alpha-synuclein in a homeless population
Objective: To study the prevalence and distribution of pathological alpha-synuclein deposition, throughout the central and peripheral nervous systems, in a homeless population. Background: The homeless…
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