Analysis of the HLA locus in isolated REM sleep behavior disorder and Lewy body dementia
Objective: To examine genetic association of HLA alleles and amino acid for isolated REM sleep behavior disorder (iRBD) and Lewy body dementia (LBD). We compare…Fatty acids and Glucocerebrosidase activity as potential biomarkers of stearyl-CoA desaturase inhibition; an observational study of inter and intraday variation in healthy volunteers and patients with Parkinson’s disease
Objective: This study aimed to assess the naturally occurring levels and variation in plasma fatty acids (FA) and ceramide metabolism in healthy volunteers (HV) and…The correlations of RBD severity with motor and nonmotor features in isolated RBD patients
Objective: To investigate the motor and nonmotor features in isolated rapid eye movement sleep behavior disorder (iRBD) and to find the variables of polysomnography (PSG)…Parkinson Progression Marker Initiative – New Science/New Cohorts
Objective: The Parkinson Progression Marker Initiative (PPMI) is expanding its cohorts and exploring additional biomarkers of PD progression to test hypotheses of the underlying molecular…Defining LRRK2-PD subsets based on olfactory function in the PPMI
Objective: A major goal of the Parkinson Progression Marker Initiative (PPMI) is to identify clinical and biomarker defined disease subsets that may demonstrate differing disease…Extensive volume increases sensitivity of alpha-synuclein accumulation in the gastrointestinal tract
Objective: This study aimed to verify whether evaluation of extensive tissue volume increases sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract in…Impaired ocular tracking in idiopathic REM sleep behavior disorder is associated with gray matter alterations
Objective: Using an established 15-min ocular-tracking task and structural MRI scanning, we examined the ocular tracking ability in iRBD patients and its anatomical correlates. Background:…Spatiotemporal dynamics in mild cognitive impairment with Lewy bodies
Objective: To explore whether EEG microstate evaluation may help in identifying mild cognitive impairment with Lewy bodies (MCI-LB) and to assess whether the changes correlate…The Global Parkinson’s Genetics Program (GP2) – a year’s progress
Objective: The Global Parkinson’s Genetics Program (GP2, http://gp2.org/) aims to dramatically expand the current understanding of the genetic architecture of Parkinson’s disease (PD) and to…Sensitive biomarker of Parkinson’s disease linked to mutations in the glucocerebrosidase gene
Objective: To find a biomarker for development of Parkinson’s disease (PD) in carriers of mutations in the glucocerebrosidase gene (GBA). Background: Mutations in the GBA…
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