Tau and α-synuclein autoantibodies as potential biomarkers for Parkinson’s and Alzheimer’s diseases
Objective: To investigate the value of the naturally occurring serum AIAs of α-synuclein (α-syn) and tau, proteins as potential biomarker for diagnosis of PD in…IGF-1 levels are associated with CSF pathology and executive dysfunction in de novo Parkinson’s disease patients
Objective: To investigate whether serum insulin-like growth factor-1 (IGF-1) is associated with clinical-neuropsychiatric, imaging and CSF markers of PD pathology in patients with early, drug-naïve…Diabetes Mellitus and Parkinson’s Disease
Objective: To investigate the association of type 2 diabetes mellitus (DM) with markers of Parkinson’s pathology in patients with early de novo Parkinson’s disease (PD).…Tyrosine kinase inhibition clears Tau and reserves neuropathology and motor symptoms in a novel model of progressive supranuclear palsy
Objective: Our objective was to examine the effects of tau accumulation in transgenic mice, observing both motor function and behavior. Background: Tau hyper-phosphorylation is a…Freezing of gait is an early clinical feature of progressive supranuclear palsy
Objective: We attempted to identify any sign or symptom to diagnose progressive supranuclear palsy (PSP) earlier. Background: Early clinical diagnosis of progressive supranuclear palsy PSP…Tau Network Genes in a Genome Wide Association Study of Progressive Supranuclear Palsy
Objective: To determine how tau network genes overlap with single nucleotide polymorphisms (SNPs) associated with Progressive Supranuclear Palsy (PSP) in a Genome Wide Association Study…Differential diagnosis and progress monitoring in Progressive Supranuclear Palsy – a potential role of pulmonary function tests
Objective: To determine the utility of pulmonary function tests in the differential diagnosis and monitoring of disease progression of Progressive Supranuclear Palsy. Background: Pulmonary complications…Results of a Phase 1, Single Ascending Dose, Placebo-Controlled Study of ABBV-8E12 in Patients with Progressive Supranuclear Palsy and Phase 2 Study Design
Objective: To present the results of a phase 1 study of ABBV-8E12 in subjects with Progressive Supranuclear Palsy (PSP) and design of a phase 2…Primary progressive apraxia: an unusual ideomotor syndrome
Objective: We describe and demonstrate by video 2 cases of primary ideomotor progressive apraxia with progressive difficulty with hand dexterity and manipulation and mild parkinsonism…Phenotypic Heterogeneity in PSP Variants – A Case Series
Objective: To present the phenotypic heterogeneity we observed in 5 PSP variants. Background: Progressive supranuclear palsy (PSP) is a primary tauopathy characterised by progressive gait…
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