Session Information
Date: Wednesday, September 25, 2019
Session Title: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Agora 3 West, Level 3
Objective: To analyze how motor complications are related to non-motor symptoms (NMS) burden in a population of early Parkinson´s disease (PD) patients.
Background: It is known that NMS burden is greater and many NMS are more prevalent in advanced PD patients with motor complications (MC). However, the relationship between NMS and MC in early PD patients has not been properly studied.
Method: PD patients from the COPPADIS cohort [1] were included in this cross-sectional study. NMS burden was defined according to the NMSS (Non-Motor Symptoms Scale) total score. UPDRS (Unified Parkinson´s Disease Rating Scale) part-IV was used to establish motor complication types and their severity. Patients with ≤ 5 years of symptoms from onset were included as early PD patients.
Results: A total of 396 PD patients (61.9 ± 9 years old, 58.1% males) with a mean disease duration of 2.7 ± 1.5 years were included. Of them, the 18.1% (75/396) and 5.8% (23/396) presented motor fluctuations and dyskinesia, respectively. NMSS total score was higher in patients with motor fluctuations (59.3 ± 44.6 vs 38.3 ± 33.4; p<0.0001) and with dyskinesia (65 ± 35.8 vs 40.9 ± 36.3; p=0.002). Scores on UPDRS-IV, UPDRS-IV-B (dyskinesias), and UPDRS-IV-A (clinical fluctuations) related to NMS burden (p<0.0001). In a multiple linear regression model and after adjustment to age, sex, disease duration, H&Y, UPDRS-III, BDI-II and levodopa equivalent daily dose, UPDRS-IV was significantly related to a higher NMSS total score (β=0.24; 95%CI 3.3-7.43; p<0.0001), as it was in a logistic regression model on dichotomous NMSS total score (≤40, mild or moderate, vs. >40, severe or very severe): OR=1.28; 95%CI 1.05-1.56; p=0.015.
Conclusion: A relationship between MC and NMS exists even in early PD patients. MC are frequent and are related to NMS burden already during the first years after diagnosis.
References: 1. Santos-García D, Mir P, Cubo E, Vela L, Rodríguez-Oroz MC, Martí MJ, et al.; COPPADIS Study Group. COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global–clinical evaluations, serum biomarkers, genetic studies and neuroimaging–prospective, multicenter, non-interventional, long-term study on Parkinson’s disease progression. BMC Neurol 2016;16:26.
To cite this abstract in AMA style:
D. Santos, T. de Deus, E. Suárez Castro, A. Aneiros, S. Jesús, M. Aguilar, LL. Planellas, J. García Caldentey, N. Caballol, B. Vives, J. Hernández Vara, I. Cabo, L. López Manzanares, I. González Aramburu, MA. Avila, MJ. Catalán, L. López Díaz, JM. García Moreno, B. Solano, M. álvarez Sauco, L. Vela, S. Escalante, E. Cubo, F. Carrillo, JC. Martínez Castrillo, P. Sánchez Alonso, MG. Alonso Losada, N. López Ariztegui, P. Martínez Martín, SG. Coppadis. Non-motor symptoms burden is greater in early Parkinson’s disease patients with motor complications [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/non-motor-symptoms-burden-is-greater-in-early-parkinsons-disease-patients-with-motor-complications/. Accessed July 1, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/non-motor-symptoms-burden-is-greater-in-early-parkinsons-disease-patients-with-motor-complications/