Session Information
Date: Wednesday, September 25, 2019
Session Title: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Agora 3 West, Level 3
Objective: To identify cut-off points on the Movement Disorders Society – Non Motor Rating Scale (MDS-NMS) for non-motor symptoms (NMS) burden grading.
Background: NMS burden increases as Parkinson disease (PD) progresses. A grading system for NMS burden using the recently developed MDS-NMS would allow for a complete and comprehensive PD patient classification when combined with the classical staging system based on motor manifestations.
Method: Data came from the multicenter, cross-sectional MDS-NMS validation study. PD patients from movement disorders clinics in United States and United Kingdom were assessed with the Hoehn & Yahr (HY) staging, the original Non-Motor Symptoms Scale (NMSS) and the new MDS-NMS. MDS-NMS mean total scores by HY stages and NMSS burden levels were calculated. Cut-off values for the MDS-NMS total score was determined using receiver operating characteristic (ROC) curve analysis, with NMSS burden levels as reference.
Results: The sample was composed by 402 PD patients, 62.2% men, that had mean age of 67.42 years old (standard deviation, SD: 9.96), mean PD duration of 8.2 years (SD: 5.93). HY stages distribution was: 51 (12.7%) patients in HY1; 219 (54.5%) in HY2; 111 (27.6%) in HY3 and 21 (5.2%) in HY4. Mean MDS-NMS total score increased with increasing HY stages (p<0.001). Using ROC curve, the following ranges of MDS-NMS burden levels were ascertained: mild, 1-44 points; moderate, 45-78; severe, 79-112; very severe, ≥113. The distribution of patients between the MDS-NMS burden levels were: mild, 141 (37.8%) patients; moderate, 90 (24.1%); severe, 51 (13.7%); and very severe, 90 (24.1%).
Conclusion: Cut-off values for categorizing PD patients based on their NMS burden using the MDS-NMS are proposed. These burden levels can complement the existing PD patients staging systems based on motor symptoms.
To cite this abstract in AMA style:
D. Weintraub, C. Rodriguez-Blazquez, A. Schrag, A. Rizos, KR. Chaudhuri, P. Martinez-Martin. Non-motor symptoms burden grading in Parkinson disease with the Movement Disorders Society – Non-Motor Rating Scale (MDS-NMS) [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/non-motor-symptoms-burden-grading-in-parkinson-disease-with-the-movement-disorders-society-non-motor-rating-scale-mds-nms/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/non-motor-symptoms-burden-grading-in-parkinson-disease-with-the-movement-disorders-society-non-motor-rating-scale-mds-nms/