Objective: To determine utility of systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) in differential diagnosis of Parkinson’s disease (PD), progressive supranuclear palsy-Richardson’s syndrome (PSP-RS) and progressive supranuclear palsy – parkinsonism-predominant (PSP-P).

Background: Current literature highlights the importance of inflammatory activity during the course of neurodegeneration. Interestingly, inflammation present in neurodegenerative disorders takes place not only in the central nervous system (CNS) but is generalized. In this context, many studies evaluate peripheral inflammatory parameters for its potential utility in differential diagnosis and connection with disease mechanisms. Recently two new parameters were introduced – SIRI, calculated according to formula: neutrophil count × monocyte count/lymphocyte count, and SII – calculated as (neutrophils × platelets) / lymphocytes. SIRI was previously used to predict pancreatic cancer survival, sepsis risk among stroke patients and in evaluation of demyelinating diseases. SII was previously described i.a. in the context of coronary heart disease, hyperlipidemia, stroke.

Method: The study included 30 patients with clinical diagnose of PD, 30 with PSP-Richardson’s Syndrome (PSP-RS), 17 with PSP-Parkinsonism Predominant (PSP-P) and 23 healthy controls. Each participant had a blood sample analysis with morphological evaluation. 

SIRI and SII parameters were calculated according to above mentioned formulas. Obtained results were analyzed statistically using Kruskal-Wallis test, which was followed by Dunn’s test to indicate possibly significant differences.

Results: No statistically significant differences were found for SIRI and SII among analyzed subgroups.

Conclusion: Neither SIRI nor SII could be used to facilitate differential diagnosis of PD, PSP-P or PSP-RS. Further studies in the field of inflammatory background of neurodegenerative diseases is required.

« Back to 2025 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/peripheral-unspecific-inflammatory-parameters-not-always-useful-in-differential-diagnosis-of-parkinsonian-syndromes/