Objective: To depict 24-hour blood pressure profile, especially dipping patterns, in individuals diagnosed with Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).

Background: Both PD and MSA often have autonomic dysfunction, which is characterized by increased blood pressure variability. Since the underlying mechanisms differ, it is important to understand this autonomic dysfunction in PD and MSA. Twenty-four-hour ambulatory blood pressure and heart rate monitoring (known as 24-hour ABPM) can offer essential data regarding the daily fluctuations in blood pressure patterns, which are commonly abnormal in individuals with PD and MSA [1].

Method: A total of nine subjects (4 PD, 5 MSA) underwent ABPM procedure. The diagnosis of PD subjects were based on the Movement Disorder Society (MDS) Criteria for Parkinson’s Disease 2015 while MSA subjects were diagnosed using the MDS Criteria for the Diagnosis of Multiple System Atrophy 2022. All subjects in the study underwent ABPM, for 24-h monitoring the Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Heart Rate (HR) continuously.

Results: The average age of PD subjects was 61,25±5,56 years old, with the onset of disease was 2,5 years (2-5 years). For MSA subjects, the average age was 53,6±10,43 years old, with the onset of disease was 6 years (3-14 years).

The study found that PD subjects had lower average systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate during daytime, nocturnal, and 24-hour period measurements compared to MSA subjects.

Abnormalities in the circadian blood pressure pattern, characterized by a non-dipping pattern, were observed in most subjects, 60% of MSA subjects and 75% of PD subjects. Nocturnal hypertension was higher in MSA subjects (60%) compared to PD subjects (25%). Furthermore, MSA subjects displayed higher nocturnal HR (nHR) (71,81 beats/min±4,82 vs 65,74±7,53) and lower nocturnal decline of HR (nDHR) (8,15%±4,96 vs 7,58%±7,03) compared to PD.

Conclusion: During 24-hour measurements, the average blood pressure and heart rate were higher in MSA compared to PD. Both MSA and PD subjects showed abnormalities in their circadian blood pressure (BP) rhythm, specifically non-dipping patterns. The occurrence of nocturnal hypertension was more prevalent in MSA. Additionally, MSA showed increased nHR and reduced nDHR compared to PD.

[table 1]

[table 2]

References: [1] Stuebner E, Vichayanrat E, Low DA, Mathias CJ, Isenmann S, Haensch CA. Twenty-four hour non-invasive ambulatory blood pressure and heart rate monitoring in Parkinson’s disease. Front Neurol. 2013;4:49. Published 2013 May 15. doi:10.3389/fneur.2013.00049

« Back to 2024 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/24-hour-ambulatory-blood-pressure-monitoring-and-dipping-patterns-in-parkinsons-disease-and-multiple-system-atrophy/