Objective: Study the relation between the side of onset of the motor symptoms in Parkinson’s Disease(PD) and motor and non-motor symptoms considering the dominant hand.

Background: It’s known that the beginning of motor symptoms in Parkinson’s Disease(PD) is asymmetric.It’s unclear if the side of onset influence the motor and non-motor symptoms progress in PD and even less known how the dominance side may be related to the evolution of the disease.

Method: It was a cross-sectional study.We included 120 patient with PD and classified them into two groups: one group that presented side of onset at right and another group at left.All of them were submitted by clinical scales:SCOPA-COG,SCOPA-PC,NMSS,and UPDRS.Information about sex, age, medical history and time with the disease were also collected.A general linear model (GLM) was applied to analyze the relation between the side of onset and score’s scales as the independent controlling for age, sex, time with disease and hand dominance(p<0,05).However, only 10 left handed were found during the study, so we performed a GLM including just the right-handed ones.

Results: The average age was 61.7±10,57 years and the average time of disease was 9,29 ± 6.8 years.69 % were men.Sixty-seven patients(55,8%) presented the first symptom on the right side, and fifty-three(44,16%)on the left. From the total sample of 120 patients, 110(91,6%) were left-handed and only 10 (8,4%) were right-handed.There was a larger proportion of the side of onset ipsilateral to hand dominance both left-handed and right-handed (Figure1).A GLM was applied to assess the relatio between scales scores from and side of onset as the independent controlling for age, sex, time of disease and hand dominance(p<0,05)only for the right-handed patients because there are only 10 left handed and the analysis about them was not possible(Table1).

Conclusion: The side of onset did not seem to influence the motor and non-motor symptoms in PD in right-handed.The most important limitation was the low number of left-handed,therefore the relation between the disease evolution and the left-handed still is unclear.Besides that, a trend was also observed showing a higher prevalence the side of onset ipsilateral to dominance side in both right-handed and left-handed.Future studies should include more left-handed individuals and applied a longitudinal evaluation to deepen the knowledge about this group in PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/association-between-the-side-of-onset-and-the-motor-and-non-motor-symptoms-in-parkinsons-disease/