Session Information
Date: Thursday, June 8, 2017
Session Title: Clinical Trials and Therapy in Movement Disorders
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To identify the association between vitamin D deficiency and PD in an Arab cohort.
Background: A growing body of evidence suggests that vitamin D deficiency may affect the incidence and progression of Parkinson’s disease, but data from ethnic populations are lacking.
Methods: Methods and Results
We studied 157 subjects (84 PD subjects and 63 controls) with mean age of 61.5 years. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Overall, 35.7% of PD subjects had lower-than-normal blood levels of vitamin D (<30 ng/mL), and 7.1% had vitamin D deficiency (<15 ng/mL), while, 15.8% of controls had low vitamin D (<30 ng/mL) which was statistically significant (p =0,0034). Mean vitamin D level in PD subjects was 46.2 ng/mL, and in controls 59.9 ng/mL (OR 3.10 ; 95% confidence interval 1.3817 to 6.9554, (P =0.0061). PD patients with early onset PD (age less than 55) were 31 and 41.9 % of them had vitamin D deficiency. However, no significant associations were found between vitamin D deficiency and early onset PD (p =0.25).
Results: We studied 157 subjects (84 PD subjects and 63 controls) with mean age of 61.5 years. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Overall, 35.7% of PD subjects had lower-than-normal blood levels of vitamin D (<30 ng/mL), and 7.1% had vitamin D deficiency (<15 ng/mL), while, 15.8% of controls had low vitamin D (<30 ng/mL) which was statistically significant (p =0,0034). Mean vitamin D level in PD subjects was 46.2 ng/mL, and in controls 59.9 ng/mL (OR 3.10 ; 95% confidence interval 1.3817 to 6.9554, (P =0.0061). PD patients with early onset PD (age less than 55) were 31 and 41.9 % of them had vitamin D deficiency. However, no significant associations were found between vitamin D deficiency and early onset PD (p =0.25).
Conclusions: The results suggest association of vitamin D deficiency [serum 25(OH)D <30 ng/mL] and PD. Further clinical studies in a larger cohort are required to determine association of Vit. D in PD.
To cite this abstract in AMA style:
A. MUJTABA, N. ALSOMALI, A. ALSHAMRANI, S. MARAR, T. Alayan, J. BAJWA. Association of vitamin D deficiency in Parkinson disease [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/association-of-vitamin-d-deficiency-in-parkinson-disease/. Accessed May 18, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/association-of-vitamin-d-deficiency-in-parkinson-disease/