MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Can post-operative local field potentials in the STN predict long-term DBS efficacy in Parkinson’s disease?

P.L Chen, H.T Wu, P.H Tu, Y.C Chen, C-C. Chen (Taoyuan City, Taiwan)

Meeting: MDS Virtual Congress 2020

Abstract Number: 665

Keywords: Deep brain stimulation (DBS), Subthalamic nucleus(SIN)

Category: Parkinson's Disease: Neurophysiology

Objective: To test whether post-operative local field potential recordings in STN could predict the long-term therapeutic efficacy in patients with PD who underwent bilateral STN DBS.

Background: STN DBS is a well established therapy for advanced PD. Predicting factors for favorable outcome including responsiveness to levodopa and baseline motor impairment before operation. Beta oscillatory activity (13–35 Hz) in the STN has been linked to akinetic–rigid symptoms in PD. However, whether the features of Beta activities recorded post-operatively could predict long-term therapeutic efficacy has yet been established. Here, we correlate the beta activity features by using a newly established ConceFT method, and the improvement of motor symptoms in PD at about 1 year after operation.

Method: 25 patients with advanced PD (7 females; age 60.4 ± 7.8 y/o; disease duration 15.2 ± 5.7 years) who underwent bilateral implantation of DBS electrodes in the STN were included in this study. Resting state local field potentials (LFPs) were obtained from 49 sides (25 right and 24 left STNs) at 3~5 days after operation. Clinical UPDRS III ON/OFF stimulation was assessed postoperatively between 6 to 18 months. Bipolar LFPs were analyzed. Powers in different frequency bands (alpha, beta, low beta, and high beta) were calculated with both traditional power spectrum and with the new “ConceFT” method [1]. All powers were normalized by the total power of 5–55 and 65–95 Hz frequency bands.

Results: Positive correlation was revealed between improvement in UPDRS‐III hemibody bradykinesia/rigidity scores, and contralateral high beta band (20–35 Hz) power (per ConceFT), most significantly at the uppermost contact pair (ρ = 0.52, P <.001). Bradykinesia or rigidity alone also gave positive correlations (ρ = 0.38, P =.007, and ρ = 0.40, P =.006, respectively). On the other hand, low beta band (13–20 Hz) power had weak positive correlation with bradykinesia (ρ = 0.30, P =.038). In broad beta band (13–35 Hz), there was positive correlation for bradykinesia/rigidity or bradykinesia alone (ρ = 0.43, P =.002, and ρ = 0.43, P =.002) but not for rigidity alone (ρ = 0.03, P =.864).

Conclusion: Our preliminary result shows that high beta activity in post-operative LFP has good predictive value of long-term stimulation efficacy in terms of bradykinesia/rigidity.

References: [1] Daubechies I, Wang Y(G), Wu H-T. 2016 ConceFT: concentration of frequency and time via a multitapered synchrosqueezed transform. Phil. Trans. R. Soc. A 374: 20150193.

To cite this abstract in AMA style:

P.L Chen, H.T Wu, P.H Tu, Y.C Chen, C-C. Chen. Can post-operative local field potentials in the STN predict long-term DBS efficacy in Parkinson’s disease? [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/can-post-operative-local-field-potentials-in-the-stn-predict-long-term-dbs-efficacy-in-parkinsons-disease/. Accessed May 13, 2025.
  • Tweet
  • Email
  • Print

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/can-post-operative-local-field-potentials-in-the-stn-predict-long-term-dbs-efficacy-in-parkinsons-disease/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • The hardest symptoms that bother patients with Parkinson's disease
  • Life expectancy with and without Parkinson’s disease in the general population
  • Patients with Essential Tremor Live Longer than their Relatives
  • #23624 (not found)
  • The hardest symptoms that bother patients with Parkinson's disease
  • Three cases of early tremor in the course of Guillain-Barré Syndrome
  • The impact of gastric acid suppressants and antacids on levodopa plasma concentration in patients with Parkinson’s disease
  • To be or not to bupropion: a drug-induced parkinsonism?
  • The Role of MRI and DaTscan in Vascular Parkinsonism: A Case Report
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley