Session Information
Date: Monday, June 20, 2016
Session Title: Epidemiology
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate the association between comorbidity profile (consisting of the cardiovascular and cerebrovascular diseases) and the prevalence of parkinsonism using data from a neuroepidemiologic community-based survey.
Background: Evidence on the association between vascular disorders and pathophysiology of Parkinson’s disease (PD) is controversial and inconsistent. Recently, an increased risk of PD has been shown in patients with untreated hypertension and ischemic cerebrovascular event such as stroke and/or TIA.
Methods: This study was a community-based door-to-door survey performed in Tehran urban area, Iran during 2012. A random cluster sampling method of the households was used through the “Healthcare Centres” network in all 22 zones throughout the entire urban area of the city. A total number of 19,500 persons aged ≥30 yr answered the baseline checklist and screening questionnaire through interviews by healthcare professionals. The screening instrument for parkinsonism consisted of a previously validated combination of six items recommended for poor-resource settings.
Results: One hundred and fifty seven cases were positively screened for parkinsonism. After multivariate adjustment for age, sex, level of education and smoking, positive history of stroke [OR=3.20 (95% CI: 1.93-5.29)], heart failure [OR=1.64 (95% CI: 1.14-2.38)] and hypertension [OR=2.05 (95% CI: 1.42-2.95)] were significantly associated with the incidence of parkinsonism. A borderline relationship was also found between the self-reported history of any malignancy and parkinsonism [OR=2.56 (95% CI: 1.00-6.58)], while no association was found between self-reported hyperlipidemia [OR=1.04 (95% CI: 0.73-1.49)], diabetes [OR=1.11 (95% CI: 0.76-1.62)], headache [OR=1.36 (95% CI: 0.92-2.02)] and epilepsy [OR=1.00 (95% CI: 0.27-3.77)].
Conclusions: Our findings showed an increased risk of parkinsonism in individuals with some cardiovascular and cerebrovascular diseases such as heart failure, hypertension and stroke. Our findings further highlight the importance of prevention and management of cardiovascular and cerebrovascular risk factors in order to decrease the prevalence of neurodegenerative diseases such as PD.
To cite this abstract in AMA style:
S.M. Fereshtehnejad, M. Shafieisabet, A. Rahmani, A. Delbari, J. Lökk. Cardiovascular and cerebrovascular disorders are associated with a higher prevalence of parkinsonism: Data from a neuroepidemiologic community-based survey [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/cardiovascular-and-cerebrovascular-disorders-are-associated-with-a-higher-prevalence-of-parkinsonism-data-from-a-neuroepidemiologic-community-based-survey/. Accessed May 13, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/cardiovascular-and-cerebrovascular-disorders-are-associated-with-a-higher-prevalence-of-parkinsonism-data-from-a-neuroepidemiologic-community-based-survey/