Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To describe clinical outcomes of pallidal stimulation in different types of dystonia, both primary and secondary and long-term results.
Background: Many studies have previously described the efficacy of deep brain stimulation for the treatment of hiperkinetic disorders. However, the benefits of stimulation for secondary dystonias are very poor. The selection of the patient and the targeting seems to be the clue to get good results.
Methods: We analyzed results from patients with primary of secondary dystonia, surgically treated with bilateral pallidal stimulation. Results from 11 patients are showed and characteristics of clinical outcome, targeting, intraoperative MRI and microrecording are described. The patients were operated under general anaesthesia with intraoperative target refinement by means of microrecording and MRI.
Results: A total of 11 patients were surgically treated during the period 2012-2017, 4 generalized dystonias and 6 focal dystonias. Secondary dystonias were tardive dystonia, dystonia associated with brain iron accumulation or calcium accumulation and dystonia due to cerebral palsy. The mean improvement in the BFM severity and disability scores was 70.4 %, by 6 months and 68 % in the TWSTRS. The results in secondary dystonia were as good as those in primary dystonias.
Conclusions: The pallidal stimulation is effective both in primary and secondary dystonia. The improvement in BFMDRS in secondary dystonias suggests that this therapy might be considered for medically intractable secondary dystonias.
References: FitzGerald JJ, Rosendal F, de Pennington N, Joint C, Forrow B, Fletcher C, Green AL, Aziz TZ. Long-term outcome of deep brain stimulation in generalised dystonia: a series of 60 cases. J Neurol Neurosurg Psychiatry. 2014. Dec;85(12):1371-6. doi: 10.1136/jnnp-2013-306833. Epub 2014 Apr 1. PubMed PMID: 24691580. Vidailhet M, Jutras MF, Grabli D, Roze E. Deep brain stimulation for dystonia. J Neurol Neurosurg Psychiatry. 2013 Sep;84(9):1029-42. doi: 10.1136/jnnp-2011-301714. Epub 2012 Nov 15. Review. PubMed PMID: 23154125.
To cite this abstract in AMA style:M. Carmona-Abellán, O. Parras, R. Valentí, J. Guridi, M. Alegre, R. Luquin-Piudo. Deep brain stimulation outcomes for primary and secondary dystonia [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/deep-brain-stimulation-outcomes-for-primary-and-secondary-dystonia/. Accessed December 5, 2023.
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