Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: To assess locus coeruleus volumes in Parkinson’s disease patients with depressive symptoms.
Background: Depression associated with Parkinson disease (PD) has a different symptom profile to endogenous depression, with high frequency and severity of anxiety. The aetiology of depression in PD remains uncertain though abnormal noradrenergic neurotransmission could play a role. We aimed to assess the integrity of locus coeruleus function via in vivoneuromelanin-sensitive MRI in antidepressant-naive patients with PD.
Method: Thirty-four patients with PD were enrolled and underwent a full clinical battery including the patient-reported Beck Depression Inventory-II (BDI-II), the clinician-reported Hamilton Rating Scale for Depression (HRSD), and the structured clinical interview for DSM-IV Axis I Disorders (SCID-I). All subjects underwent a 3T neuromelanin-sensitive MRI.
Results: Ten of 34 patients with PD (29.4%) had BDI-II and HRSD scores above the discriminative cut-off for PD depression though only half of these patients could be classed on SCID-I criteria as having an anxiety/mood disorder. Patients with PD with the highest scores for depression symptoms showed significantly lower volume of locus coeruleus (P<0.05) on neuromelanin-sensitive MRI compared to low score cases, and lower volume of locus coeruleus was correlated with higher BDI-II (r=0.671, P<0.001) and HRSD scores (r=0.751, P<0.001).
Conclusion: Depressive symptoms in antidepressant-naive patients with PD correlate with lower volume in the locus coeruleus possibly reflecting lower extracellular noradrenaline levels. Our data are compatible with a key role of abnormal noradrenergic neurotransmission contributing to the pathophysiology of PD depression. This abstract was also submitted for presentation at the 2019 European Academy of Neurology Conference.
To cite this abstract in AMA style:C. Farrell, G. Pagano, E. de Natale, M. Politis. Depressive Symptoms are Associated with Lower Locus Coeruleus Volumes in Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/depressive-symptoms-are-associated-with-lower-locus-coeruleus-volumes-in-parkinsons-disease/. Accessed December 2, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/depressive-symptoms-are-associated-with-lower-locus-coeruleus-volumes-in-parkinsons-disease/