Session Information
Date: Wednesday, June 22, 2016
Session Title: Rating scales
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To analyze the MDS-UPDRS part I-IV scores and their differences based on Hoehn and Yahr stage (HY) and disease duration in a large cohort of Parkinson’s disease (PD) patients.
Background: The MDS-UPDRS is a newly developed comprehensive tool to assess PD, its change over the course of PD including increasing disease duration and HY stages has not been well described.
Methods: This cross-sectional study collected demographic data and MDS-UPDRS scores including HY. MDS-UPDRS part I-IV subscores were analyzed using one-way ANOVA for each HY stage and for 5-year increments in disease duration.
Results: Mean participant age of the 3206 patients was 65.8±10.6 years, 53.3% were men, mean disease duration was 11.5±4.6 years and median HY was 2 (range 0-5). Scores of all four MDS-UPDRS parts increased significantly through HY stages 1-5, with and average increase of 3.8; 7.7; 14.6; and 2.0 points consecutively for parts I-IV, respectively. For 5-year increments in disease duration, MDS-UPDRS subscores increased by an average of 1.6; 3.3; 4.2; and 1.4 points consecutively for parts I-IV, respectively. This increase was significant during the first 15 years of disease for all four parts, while parts II, III and IV increased significantly also in the 15-20 year interval and only part II increased significantly in the 25 and more years interval. There was no change observed in the 20-25 year interval for any MDS-UPDRS part.
Conclusions: MDS-UPDRS scores for all four parts significantly increase with every HY stage and also with 5-year increments in disease duration in the first 15 years of the disease.
Submitted for EAN Congress in Copenhagen May 28-31 2016.
To cite this abstract in AMA style:
M. Skorvanek, P. Martinez-Martin, N. Kovacs, I. Zezula, M. Rodriguez-Violante, J.C. Corvol, P. Taba, K. Seppi, O. Levin, A. Schrag, T. Foltynie, M. Alvarez-Sanchez, T. Arakaki, Z. Aschermann, I. Aviles-Olmos, E. Benchetrit, C. Benoit, A. Bergareche-Yarza, A. Cervantes-Arriaga, A. Chade, F. Cormier, V. Datieva, D.A. Gallagher, N. Garretto, Z. Gdovinova, O. Gershanik, M. Grofik, V. Han, J. Huang, L. Kadastik-Eerme, M.M. Kurtis, G. Mangone, J.C. Martinez-Castrillo, A. Mendoza-Rodriguez, M. Minar, H.P. Moore, M. Muldmaa, C. Mueller, B. Pinter, W. Poewe, K. Rallmann, E. Reiter, C. Rodriguez-Blazquez, C. Singer, B.C. Tilley, P. Valkovic, C.G. Goetz, G.T. Stebbins. Differences in MDS-UPDRS scores based on Hoehn and Yahr stage and disease duration: Results of a large international multicenter study of 3206 patients (the QUALPD study) [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/differences-in-mds-updrs-scores-based-on-hoehn-and-yahr-stage-and-disease-duration-results-of-a-large-international-multicenter-study-of-3206-patients-the-qualpd-study/. Accessed May 18, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/differences-in-mds-updrs-scores-based-on-hoehn-and-yahr-stage-and-disease-duration-results-of-a-large-international-multicenter-study-of-3206-patients-the-qualpd-study/