Session Time: 1:15pm-2:45pm
Location: Agora 3 East, Level 3
Objective: to assess prodromal Parkinson disease (PD) probability and relate it to detailed cognitive performance in a community cohort.
Background: There is a limited information on cognitive function before PD clinical onset in the general population.
Method: In a population-based cohort of 1629 dementia and PD free participants ≥65 in two regions of Greece, probability of prodromal PD was assessed according to Movement Disorder Society (MDS) criteria. Cognitive performance in 5 cognitive domains was assessed by a detailed neuropsychological battery. Clinical cognitive diagnoses (cognitively unimpaired, mild cognitive impairment (MCI), dementia) were assigned in consensus conferences. We investigated associations between prodromal PD probability (and its individual constituents) and cognitive outcomes. All composite z-scores were constructed from cognitive tests.
Results: The median probability of prodromal PD was 1.81%, (0.2 to 96.7%). Probability of prodromal PD was significantly higher in participants with MCI compared to those with normal cognition (p<0.001). Higher probability of prodromal PD was related to lower performance in all cognitive domains (memory, language, executive, attention, and visuospatial function) (p<0.001). Lower cognitive performance was further associated with certain non-motor markers of prodromal PD, such as daytime somnolence, depression, urinary dysfunction, constipation and sub threshold parkinsonism (p<0.001).
Conclusion: Higher probability of prodromal PD was associated with lower cognitive performance in all domains and higher probability of MCI. This may reflect a widespread pathological process although future studies are warrant to infer causality. These results suggest to clinicians, that they should assess cognition early, and to researchers that they should further look into the possible mechanisms that may underlie this observation.
To cite this abstract in AMA style:A. Bougea, M. Maraki, M. Yannakoulia, M. Stamelou, G. Xiromerisiou, M. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, C. Anastasiou, L. Stefanis, N. Scarmeas. Higher probability of prodromal Parkinson’s disease is related to lower performance in all cognitive domains [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/higher-probability-of-prodromal-parkinsons-disease-is-related-to-lower-performance-in-all-cognitive-domains/. Accessed December 7, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/higher-probability-of-prodromal-parkinsons-disease-is-related-to-lower-performance-in-all-cognitive-domains/