Category: Parkinson’s Disease: Clinical Trials
Objective: To identify the Neurocognitive Functioning (NF) in a patient with IPDWD and intervened by DBS, and to analyze the impact of functional neurorehabilitation (FNR) for the improvement of quality of life (QOL) in cognitive, social and individual aspects.
Background: IPDWD is a pathology characterized by motor symptoms such as bradykinesia, rigidity and resting tremor, non-motor symptoms such as depression, anxiety and neurocognitive alterations. DBS is a procedure that allows improving motor symptoms in patients with IPDWD, it has been found that in the first post-surgical month patients present alterations in their NF, especially in planning and decisions domains, however FNR plans allow improving NF in these patients
Method: Case study with transectional design. Right-handed patient, with basic schooling, who underwent surgery for DBS. An evaluation protocol was applied by Clinical Neuropsychology before and after surgery, to identify the NF in the patient, and to apply a FNR treatment to improve his task resolution in cognitive aspects such as attention, memory and executive functions.
Results: Data obtained by the assessment protocol prior to DBS indicate impairment in the following domains: Attention TMT-A (2’46”), TMT-B (3’40”), Weschler Scale Digit Retention Scale (direct order: 6, reverse order: 2), SCOPA-COG (26), PD-CRS (70), FAB (14/18), Hopkins Verbal Test-A (3/12), Hopkins verbal Test-B (3/12) MoCA (24/30), Copy Clock Test (6/10), Order Clock Test (7/10), Yesavage Depression Scale (30/30), HRSA Anxiety Scale (48/54). Assessment results 6 months after surgery with treatment by FNR at 1 month after DBS: Attention TMT-A (1’10”), TMT-B (1’36), Weschler scale digit retention scale (direct order: 10, reverse order: 6), SCOPA-COG (34), PD-CRS (86), FAB (17/18), Hopkins Verbal Test-A (7/12), Hopkins verbal Test-B (9/12) MoCA (29/30), Copy Clock Test (10/10), Order Clock Test (10/10), Yesavage Depression Scale (6/30), HRSA Anxiety Scale (10/54).
Conclusion: FNR has improved the NF in a patient with IPDWD. Neuropsychology is a non-pharmacological treatment that allows slowing neurocognitive deterioration in patients with IPDWD, and contributes to the improvement of QOL in individual and familiar aspects.
To cite this abstract in AMA style:
C A. Hurtado-Gonzalez, J F. Ayala-Rico, S. Ospina-Otalvaro, P A. Lenis, J M. Márquez, C O. Moreno, M. Agudelo, S. Guerrero. Neurocognitive Functioning (NF) in a Patient with Idiopathic Parkinson’s Disease without Dementia (IPDWD). Subjected to Deep Brain Stimulation (DBS) and Treatment by Clinical, Functional and Advanced Neuropsychology. [abstract]. Mov Disord. 2024; 39 (suppl 1). https://www.mdsabstracts.org/abstract/neurocognitive-functioning-nf-in-a-patient-with-idiopathic-parkinsons-disease-without-dementia-ipdwd-subjected-to-deep-brain-stimulation-dbs-and-treatment-by-clinical-functional-and-advanced/. Accessed October 4, 2024.« Back to 2024 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/neurocognitive-functioning-nf-in-a-patient-with-idiopathic-parkinsons-disease-without-dementia-ipdwd-subjected-to-deep-brain-stimulation-dbs-and-treatment-by-clinical-functional-and-advanced/