Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: In this study, we have evaluated, in one hand, the neurotoxic effect of Pb (25 mg / kg B.W i.p) for three consecutive days on dopaminergic system and locomotor performance in Merione shawi. In the other hand, the possible restorative potential of C. sativus (CS) (50 mg / kg BW) by oral gavage.
Background: The Pb can cause structural and functional disruption of the nervous system. Studies have shown that exposure to Pb has been considered a risk factor in the development of Parkinson’s disease (PD). Therefore, we aimed to evaluate the neurotoxic effect of Pb and the possible restorative potential of the aqueous extract of C. sativus (CSAE) on dopaminergic, noradrenergic systems and locomotor performance in Merione shawi.
Method: Animals were divided into 4 groups. Group I: control meriones (C) injected i.p. with physiological saline buffer (0.9% NaCl), Group II: meriones (Pb) injected i.p. with Pb (25 mg/kg B.W), Group III: meriones (CS+Pb) received aqueous extract of C. sativus (CSAE) (50 mg/kg B.W) by oral gavage, These meriones were injected i.p. with Pb (25 mg/kg B.W) 2h after the last dose of C. sativus and Group IV: meriones (CS) that received only CSAE (50 mg/kg B.W) by oral gavage and injected i.p. with physiological saline buffer (0.9% NaCl) for three consecutive days.
Results: The immunohistochemical approach has revealed that intoxicated Meriones showed an increase in the tyrosine hydroxylase (TH) levels in the substantia nigra compacta (SNc) locus coeruleus (LC), dorsal striatum (DS), medial forebrain bundle (MFB), unlike the other groups. After treatment with CSAE, our results showed that this extract has a real potential to prevent all Pb-induced damages.
Conclusion: We have demonstrated a new pharmacological property of Crocus sativus that can be used against lead neurotoxicity and as a neuroprotective product for PD.
To cite this abstract in AMA style:
L. Tamegart, A. Abbaoui, R. Makbal, M. Zroudi, M. Bouyatas, B. Bouizgarne, H. Gamrani. Neuroprotective effect of crocus sativus in lead-induced dopaminergic neurotoxicity in Meriones shawi: A possible link with Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/neuroprotective-effect-of-crocus-sativus-in-lead-induced-dopaminergic-neurotoxicity-in-meriones-shawi-a-possible-link-with-parkinsons-disease/. Accessed May 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/neuroprotective-effect-of-crocus-sativus-in-lead-induced-dopaminergic-neurotoxicity-in-meriones-shawi-a-possible-link-with-parkinsons-disease/