Session Time: 1:15pm-2:45pm
Location: Hall 3FG
Objective: The aim of this study is to describe the prevalence and burden of NMS in a group of PD patients without dementia compared to an age-matched control group.
Background: Non-motor symptoms (NMS) are frequent in patients with Parkinson’s disease (PD) and impact quality of life.
Methods: This is a descriptive study conducted in Spain using data from the baseline visit of the COPPADIS-2015 Study (Santos García et al. BMC Neurol 2016;16:26), an observational, descriptive, 5-year follow-up, national, multicenter, evaluation study. The prevalence and burden of NMS were evaluated using the Non-Motor Symptoms Scale (NMSS), a scale that assess 30 non-motor items grouped in 9 domains.
Results: 696 patients (mean age 62.77 ± 9.03, males 59.7%) and 206 controls (mean age 61.16 ± 8.45, males 49.8%) were included in the analysis. NMS were more prevalent in PD patients than controls (total prevalence: 99.3% vs 84.9%, p<0.0001). The mean number of domains affected was 5.74 ± 2.10 in PD group vs 3.25 ± 2.24 in control group (p<0.0001). PD patients had higher prevalence and burden of NMS in all domains and also in all items except “difficulty falling asleep” and “altered sexual interest”. Fatigue (62.2%), nocturia (61.2%) and urinary urgency (60.5%) were the most common NMS in the PD group while nocturia (43.2%), difficulty falling asleep (34.0%) and altered interest in sex (32.0%) were the most frequent in control group. Among patients, females had higher scores than males in items related to mood while males had higher scores in daytime sleepiness and sialorrhea. Postural instability and gait difficulty (PIGD) phenotype was associated with higher total NMSS score than tremor dominant PD (51.31 ± 40.96 vs 40.07 ± 34.82; p=0.004) and higher scores in sleep/fatigue, mood/apathy, gastrointestinal and miscellaneous domains too.
Conclusions: In our study PD patients have more NMS with higher NMSS scores than controls. Moreover, our results suggest that NMS could be influenced by gender and PD phenotype.
To cite this abstract in AMA style:L. Planellas, M. Martí, P. Santacruz, A. Cámara, S. Jesus Maestre, F. Carrillo García, P. Mir, M. Aguilar, P. Pastor, J. García Caldentey, E. Estelrich Peyret, N. Caballol Pons, I. Legarda, B. Vives Pastor, J. Hernández Vara, G. Martí Andrés, I. Cabo, L. López Manzanares, M. Gallego-de-la-Sacristana, P. Martínez Martín, D. Santos García, G. COPPADIS STUDY. Non-motor symptoms in Parkinson’s Disease: Frequency, types and correlated factors compared to a group of healthy controls. Results from the COPPADIS Study Cohort [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/non-motor-symptoms-in-parkinsons-disease-frequency-types-and-correlated-factors-compared-to-a-group-of-healthy-controls-results-from-the-coppadis-study-cohort/. Accessed November 29, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/non-motor-symptoms-in-parkinsons-disease-frequency-types-and-correlated-factors-compared-to-a-group-of-healthy-controls-results-from-the-coppadis-study-cohort/