MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Opicapone and entacapone as add-on therapy to the treatment of infusions of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease

J.C Martinez Castrillo, I. Parees Moreno, G. Sanchez Diez, A. Alonso Cánovas (Madrid, Spain)

Meeting: MDS Virtual Congress 2020

Abstract Number: 1035

Keywords: COMT inhibitors, Levodopa(L-dopa), Parkinsonism

Category: Parkinson’s Disease: Pharmacology and Therapy

Objective: To study the effect of COMT inhibitors (opicapone and entacapone) in Parkinson’s disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) and an insufficient control of motor symptoms.

Background: LCIG is an effective treatment for patients with advanced PD. Addition of a COMT inhibitor, that blocks levodopa’s second-largest pathway, leads to less levodopa conversion to 3-O-methyldopa (3-OMD), increasing the concentration of levodopa in plasma. In addition, as 3-OMT competes with levodopa to pass the blood brain barrier, COMTis allow more levodopa to enter the brain. Finally, the inhibition of COMT reduces the concentration of some levodopa metabolites that could have a neurotoxic effect and the requirements of vitamins B12, B6 and folic acid.

Method: Retrospective analysis of patients undergoing treatment with LCIG who presented an insufficient motor control despite several infusion adjustments.  Opicapone was added when there were predictable fluctuations several times a day or unpredictable fluctuations, while entacapone was added for predictable fluctuations, usually postprandial. Both drugs were prescribed once a day. The dose of levodopa was reduced about a 10% only with opicapone. Fluctuations were measured with Hauser’s diaries. Homocysteine ​​levels were studied before and after treatment. All patients were on vitamin B12 and folic acid supplements.

Results: Sixteen patients mean age 72,2 + 6.5 years, evolution of PD 9,5 + 7,3 years (11 opicapone, 5 entacapone; 8 and 2 with LCIG 24 hours respectively). Daily mean dose of LCIG was 1321,4 mg in the opicapone group and 1028,7 mg in entacapone one. All patients had motor fluctuations and 6/11 also had unpredictable fluctuations. Opicapone reduced OFF time by 1.2 + 0.9 hours (range 0,0-3,1, p = 0,2), and entacapone by 0,2 + 0,2 (range 0,0-0,5). The mean dose reduction of levodopa was 16 + 21 mg/hour, 235,2 mg/day, a 17.8% reduction; the number of extra doses used was reduced from 4,6 to 2,1. A cost analysis yielded a reduction in the cost of LCIG of 3540 euros per patient and year, once opicapone costs were discounted. There were no differences between basal and follow-up homocysteine ​​levels.

Conclusion: Opicapone and entacapone may be useful for controlling motor fluctuations of patients with PD undergoing treatment with LCIG when therapeutic adjustment is insufficient.

To cite this abstract in AMA style:

J.C Martinez Castrillo, I. Parees Moreno, G. Sanchez Diez, A. Alonso Cánovas. Opicapone and entacapone as add-on therapy to the treatment of infusions of levodopa-carbidopa intestinal gel in patients with advanced Parkinson’s disease [abstract]. Mov Disord. 2020; 35 (suppl 1). https://www.mdsabstracts.org/abstract/opicapone-and-entacapone-as-add-on-therapy-to-the-treatment-of-infusions-of-levodopa-carbidopa-intestinal-gel-in-patients-with-advanced-parkinsons-disease/. Accessed May 15, 2025.
  • Tweet
  • Email
  • Print

« Back to MDS Virtual Congress 2020

MDS Abstracts - https://www.mdsabstracts.org/abstract/opicapone-and-entacapone-as-add-on-therapy-to-the-treatment-of-infusions-of-levodopa-carbidopa-intestinal-gel-in-patients-with-advanced-parkinsons-disease/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Yerba Mate (Ilex paraguaiensis) protects dopaminergic neurons degeneration and improve their maturation in culture
  • #26133 (not found)
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley