a-synuclein neurotoxicity and spreading using Lewy Body extracts from Parkinson Disease Brains: In vitro screening by cell-based assays
Objective: To define the kinetics of neuronal and astrocytic abnormalities induced by human-derived α-syn aggregates for grounding the use of such system to identify and…Anti-synuclein alpha antibodies and IL-1β at Parkinson Disease (PD).
Objective: Determine a correlation between the levels of anti-synuclein alpha antibodies and IL-1β at serum and CSF of patients with PD. Background: PD is a…Admixing augments nigral dopaminergic correlates during development to impart resistance to MPTP-toxicity at adulthood
Objective: Establish the developmental basis for varying nigral dopaminergic (DA) correlates in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) susceptible C57BL/6, MPTP resistant CD-1 and their resistant crossbred mice. Background:…Dopamine substitution restores effective connectivity between prefrontal and premotor areas in Parkinson’s disease
Objective: To assess influences of dopamine deficiency on the causal interplay within the motor network during bimanual finger tapping in Parkinson's disease (PD) patients. Background:…Assessment of neurodegeneration and spreading of α-synuclein pathology induced by structurally defined α-synuclein assemblies in wild-type mice
Objective: The aim of this study was to investigate, in wild-type mice, the spreading and neurodegeneration induced by intracerebral injection of structurally well-defined α-synuclein assemblies…Serum lipid profile in Parkinsons disease patients from Southern Spain
Objective: Our first aim was to evaluate differences in the blood lipid profile levels between Parkinsons disease (PD) patients and healthy controls (HC). Secondly, in…Expression of late cell cycle markers in Parkinson Disease and Lewy Body Dementia
Objective: The objective of this study is to determine the expression of late cell cycle markers in Parkinson Disease (PD) and Lewy Body Dementia (LBD) Background:…Premovement betaband event-related desynchronization related to simple lower limb movement and simulated gait initiation in Parkinson’s disease patients: MEG study
Objective: To compare premovement event related desynchronization (ERD) between simple lower limb movement and simulated gait initiation in Parkinson’s disease (PD) patients using Magnetoencephalography (MEG).…Antibody binding differences in alpha-synuclein from Parkinson’s disease and multiple system atrophy
Objective: Determine whether alpha-synuclein derived from Parkinson's disease (PD) and multiple system atrophy (MSA) brains has different conformations as defined by biochemical and antibody-based approaches. Background: There…Development of nano-formulation containing crocetin for the protective and beneficial effect against 6-hydroxydopamine induced Parkinson’s disease model via altered the genetic backgrounds
Objective: Parkinson’s disease (PD) induced by the interaction between the number of factors viz., aging, genetics toxins, mitochondrial deformity and oxidative stress. Various evidences suggest…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.