Session Information
Date: Saturday, October 6, 2018
Session Title: Surgical Therapy: Parkinson's Disease
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: This study was a comparative studies of the efficacy of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) under general anesthesia (GA) in mainland of China.
Background: Deep brain stimulation has been shown to be superior to the best medical therapy in improving motor function and quality of life in advanced Parkinson disease. Today, there are two different anesthesia for PD patients to choose, traditional DBS conducted while the patient is awake with local anesthesia, and new general anesthesia for PD patients who cannot tolerate awake DBS, can be performed under asleep DBS. We assess the efficacy and safety by compare motor disability relief, reduction of dopaminergic medication, and adverse effects between the two.
Methods: 32 patients were assigned to the GA group and 16 patients were assigned to the LA group, we compared the middle-term outcome of patients under GA with those who were operated on under local anesthesia (LA) after at least 6 months after surgery.
Results: Motor outcome: There was no significant difference on the UPDRSIII scores in either groups in 6 months fellow-up. Non-motor outcome: The overall non-motor outcome did not show difference except that the levodopa equivalent daily dose (LEDD) showed a greater decline in GA group, the score of MOCA was improved in LA group and the score of NMSS better in GA group in 6 months fellow-up. Adverse effects: There was no significant difference on the incidence of adverse effects in either groups except that the incidence of temporary hiccup was significantly higher in the GA group.
Conclusions: Asleep-DBS can be considered as a good alternative method for PD patients undergoing DBS. Although DBS under general anaesthesia may lead to more side effects, the improvement in motor outcome showed no significant difference between the two groups and a significant greater decline in LEED may be seen in the GA group.
To cite this abstract in AMA style:
W. Chen, L. Chen. The efficacy and safety of STN-DBS under general anesthesia for PD patients [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/the-efficacy-and-safety-of-stn-dbs-under-general-anesthesia-for-pd-patients/. Accessed May 15, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-efficacy-and-safety-of-stn-dbs-under-general-anesthesia-for-pd-patients/