Substantia Nigra Free-Water, Metabolic Markers, and Motor Variability in Older Adults with Diabetes
Objective: To examine whether nigral microstructural integrity measured via substantia nigra free-water MRI (FW-MRI) relates to peripheral metabolic burden and motor variability across the glycemic…Attention-Enhanced Deep Learning for Midbrain MRI Segmentation in Parkinson’s Disease
Objective: To develop an automated deep learning framework for robust midbrain segmentation in MRI data of Parkinson’s disease patients. Background: Structural alterations in the midbrain…Unravelling the neural correlates of visual cueing in Parkinson’s disease
Objective: Visual cueing can compensate for impaired automatic gait control in Parkinson's disease (PD) patients experiencing Freezing of Gait (FOG) by engaging goal-directed motor behaviour1.…Social Network Structure and Caregiving Experiences in South Asian Families Living with Dementia Associated with Parkinsonian Disorders
Objective: To characterize social network structure and caregiving among SA families with Parkinsonian dementia (PD) and compare them with White American (WA) caregiving networks. Background:…Cholinergic Basal Forebrain Atrophy Associates with Short-Latency Afferent Inhibition and Cognitive Impairment in Parkinson’s Disease
Objective: To investigate whether cholinergic basal forebrain (cBF) atrophy mediates the relationship between short-latency afferent inhibition (SAI) and cognitive performance in PD. Background: Cognitive impairment…Clinical Utility of DaT-SPECT as a Predictive Tool for the Development of Parkinson’s Disease and Related ɑ-synucleinopathies in REM-Behavior Disorder
Objective: The aim of this systematic review was to analyze the available literature and evaluate the efficacy of DaT-SPECT for the prediction of PD phenoconversion…Differential expression of nucleotide excision repair genes in Parkinson’s disease
Objective: To compare the relative expression of XPC, XPA, ERCC5, and ERCC4 between patients with Parkinson’s disease (PD) and controls. Background: DNA damage and impaired…Harmonized Analysis of Parkinson’s Disease-Associated Variants in the AfrAbia PD Genomic Consortium Cohort
Objective: To characterize the genetic architecture of Parkinson's disease (PD) in an understudied African-Arab cohort by analyzing pathogenic variants in known PD genes across releases…DTI-ALPS index and its association with dopamine loss, brain metabolism, and motor and cognitive manifestations in Parkinson’s disease
Objective: This study aimed to investigate the clinical relevance of glymphatic dysfunction in Parkinson's disease (PD) by integrating the diffusion tensor imaging (DTI) analysis along…Homozygous PRRT2 Frameshift Mutation Presenting with Infantile Onset Seizures and Childhood Episodic Ataxia
Objective: To report a rare presentation of a homozygous PRRT2 frameshift mutation manifesting as infantile-onset seizures followed by childhood episodic gait imbalance. Background: PRRT2 mutations…
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