Serum fractalkine levels in Parkinson’s disease: Evidence for neuroinflammation
Objective: Parkinson's disease (PD) is a debilitating neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra. We measured neuroinflammatory marker fractalkine in…Atypical Dopamine Responsive Parkinsonism in HIV Seroconversion
Objective: To add to the current body of knowledge of the association of HIV infection and dopamine responsive parkinsonism. Background: South Africa has one of…Quantitative Midbrain Measurement in Diagnosing Variants of Progressive Supranuclear Palsy
Objective: To evaluate the effectiveness of quantitative midbrain measurements in differentiating vPSP from multiple system atrophy (MSA) and Parkinson’s disease (PD). Background: Newly published criteria…ARISE study: Study Design and Baseline Characteristics for a Phase 2 Trial of the Anti-Tau Antibody ABBV-8E12 in Progressive Supranuclear Palsy
Objective: This double-blind, placebo-controlled phase 2 study (M15-562 ARISE study, NCT02985879) assesses the safety and efficacy of ABBV-8E12 treatment in patients with progressive supranuclear palsy…Striatal FP-CIT SPECT findings for progressive supranuclear palsy subtypes
Objective: In our previous study FP-CIT SPECT (FP-CIT) in progressive supranuclear palsy-Parkinsonism (PSP-P) revealed higher anterior striatal accumulation, and PSP- Richardson’s syndrome (PSP-RS) revealed lower…A longitudinal study of brain quantitative MRI analysis before and after diagnosis of progressive supranuclear palsy
Objective: We analyzed longitudinal change in MRI imaging in PSP from the period before clinical diagnosis. Six patients with clinically diagnosed PSP including 1 case…Cognitive impairment in multiple system atrophy: A Nepalese tertiary center study
Objective: This study was done to describe the clinical profile of MSA and evaluate the cognitive function using mini-mental state examination(MMSE). Background: Multiple system atrophy…Probable MSA presenting initially with urinary retention
Objective: We describe 6 cases of probable MSA presenting with urinary retention/incomplete bladder emptying. Background: MSA is a progressive neurodegenerative adult-onset disease whose clinical features…Toxin-induced Parkinsonism: A report of two patients
Objective: To highlight the presentation of parkinsonism caused by acute and chronic exposure to carbon monoxide(CO). Background: Toxin-induced parkinsonism is not uncommon. One of the…MRI volumetrics in parkinsonian syndromes
Objective: We aimed to explore the ability of MRI volumetrics by using an automated segmentation software called Accubrain in differentiating (1) between different parkinsonian syndromes…
