Levodopa responsiveness in Parkinson’s disease is significantly impaired in those with diabetes and increased vascular risk.
Objective: To define variation in L-dopa response in recent onset PD. Background: L-Dopa responsiveness is a defining feature of Parkinson’s disease (PD), but the degree…Efficacy and safety of incobotulinumtoxinA (inco/A) for essential tremor using kinematics-guided clinical decision support: A randomized, double-blind, placebo-controlled trial
Objective: To demonstrate improvement of arm tremor severity and hand function with kinematics-guided inco/A therapy Background: Botulinum neurotoxin A (BoNT-A) therapy of debilitating tremor symptoms…Rationale and Design of a Phase 2 Study to Evaluate the Efficacy of Intepirdine (RVT-101) in Improving Gait and Balance in Patients with Dementia
Objective: To describe the rationale and design of a Phase 2 study that evaluates the effect of intepirdine (RVT-101) on gait and balance in patients…A Phase 2 Study of Nelotanserin, a Novel 5HT2A Receptor Inverse Agonist, in Dementia with Lewy Bodies and Parkinson’s Disease Dementia Subjects Experiencing Visual Hallucinations
Objective: To evaluate the safety and efficacy of nelotanserin in Lewy body dementia subjects experiencing visual hallucinations. Background: Nelotanserin is a selective 5HT2A receptor inverse…Efficacy and Safety of a 2 mL Dilution of AbobotulinumtoxinA Compared With Placebo in Adult Patients With Cervical Dystonia
Objective: To determine the efficacy and safety of a 500 U/2 mL dilution of aboBoNT-A as compared to placebo in patients with cervical dystonia (CD).…Rehabilitation program with or without a whey protein-based nutritional support enriched with essential aminoacids and vitamin D in patients with Parkinson’s disease or parkinsonism: study design of a randomized, controlled trial.
Objective: Objective. To evaluate whether the use of a whey protein-based nutritional formula enriched with essential aminoacids – particularly leucine - and vitamin D have…A randomised control trial to investigate if people with Parkinson’s disease can exercise at high intensity, and does this improve their cardiorespiratory function? A feasibility study
Objective: To assess whether people with Parkinson’s disease (PD) are able to exercise at ≥85% of maximal heart rate during High Intensity Interval Training (HIIT)…Are the exergaming effective for improving functional exercise capacity, and quality of life in Patients with Parkinson’s Disease?
Objective: To analyze the effects of exergaming on functional exercise capacity and quality of life in patients with Parkinson's disease Background: The use of technology,…A Phase 2, Open-Label, Dose-Escalating Study to Evaluate the Safety and Preliminary Efficacy of Daxibotulinumtoxina for Injection (RT002) in Isolated Cervical Dystonia
Objective: To report preliminary 24-week outcomes of an open-label trial of daxibotulinumtoxinA for injection (RT002) for the treatment of isolated cervical dystonia (CD). (ClinicalTrials.gov ID: NCT02706795) Background:…Motor and Body Composition Variables by Parkinson’s Disease Staging
Objective: Knowing the motor variables involved in the relationship of body composition and staging of disease. Background: Functional limitation, defined as a restriction in the…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.