Neuroprotective Effects of Thymol in MPTP-Induced Parkinson’s Disease Model in Rats: Molecular Docking, Behavioral, Biochemical, and Histological Investigations
Objective: This study aimed to investigate the neuroprotective potential of thymol in an MPTP-induced Parkinson’s disease (PD) model in rats, focusing on its ability to…Targeted Brain Delivery of Rifampicin via PEG-PLA Nanoparticles: A Promising Therapeutic Strategy for Neuroprotection and Disease Modification in Parkinsonian Mouse Models
Objective: This study aimed to design and validate a nanoparticle-based delivery system for rifampicin, with the objective of enhancing its therapeutic efficacy, improving brain targeting,…Protective effects of Hesperidin loaded polymeric nanoparticles on the progression of MPTP Induced Parkinson’s disease via targeting GPR43/NLRP3 signaling pathway: in vitro and in vivo studies
Objective: Emphasizing the G protein-coupled receptor 43 (GPR43) and the NLRP3 signaling pathway in both in vitro and in vivo models, this work studies the…Real-World Experiences with VMAT2 Inhibitors in Pediatric Hyperkinetic Movement Disorders
Objective: We review the real-world prescribing practices and patient experiences with VMAT2 inhibitors in children. Background: Vesicular monoamine transporter 2 (VMAT2) inhibitors are often prescribed…Drug-Induced Movement Disorders in Elderly Patients with Dementia: A Case Study of Acute Dystonia Following Third-Generation Antipsychotic Use
Objective: To represent a case of acute dystonic dyskinesias after breхpiprazole use by the patient with frontotemporal dementia (behavioral variant) Background: Drug-induced movement disorders (DIMDs)…Bidirectional Relationships Between Frailty and DNAm Age Acceleration and its Mediation Effects on Physical Disability and Mortality
Objective: This study aims to investigate the bidirectional associations between frailty and DNA methylation (DNAm) age acceleration (AgeAccel), and further test whether epigenetic aging mediates…Perinatal Dioxin Exposure and Dopaminergic Vulnerability in the Development of Motor Dysfunction Sequelae
Objective: To investigate the impact of dioxins on movement disorder development and the mechanisms increasing vulnerability to future motor dysfunction. Background: Dioxins are persistent organic…Enhancing Sleep in Parkinson’s Disease: A Retrospective Study on Group CBT-I
Objective: Weill Cornell Sleep Center and our movement disorder team developed a treatment program for individuals with Parkinson’s Disease (PD) with sleep disturbances. The goal…Gut Dysbiosis Alters Host Metabolism but Does Not Independently Induce Parkinson’s Disease Pathology
Objective: To determine whether gut dysbiosis alone is sufficient to induce Parkinson’s disease (PD) pathology and to investigate its impact on host metabolism. Background: Gut…Physical, Mental, and Socioemotional Functional Improvement Following Valbenazine Treatment for TD: a Case Series
Objective: Describe clinical characteristics and changes in mental, socioemotional, and physical domains of individuals with tardive dyskinesia (TD) after valbenazine (VBZ) treatment. Background: Prior research…
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