MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2016 International Congress

    Mitochondrial response precedes intracellular accumulation of α-synuclein in Parkinson’s disease

    I. Milenkovic, E. Dassler, M. Weber, G.G. Kovacs (Vienna, Austria)

    Objective: To investigate the expression of mitochondrial COX-IV during the progression of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the…
  • 2016 International Congress

    Chronic cerebral hypoperfusion accelerates cognitive dysfunction and microvascular impairment in the MPTP mouse model of Parkinson’s disease

    H. Tang, R. Zhu, L. Gao, K. Nie, S. Feng, Z. Duan, Y. Zhang, X. Zhao, L. Wang, J. Zhao, Z. Huang, Y. Zhang, L. Wang (Guangzhou, People's Republic of China)

    Objective: To evaluate cerebral hypoperfusion on cognitive dysfunction and related microvascular impairment in the MPTP mouse model. Background: Vascular pathology and Parkinson's disease (PD) pathology…
  • 2016 International Congress

    Lessons learned from the Nilotinib trial: Cardio-vascular conditions in parkinsonism

    Y. Torres-Yaghi, A. Keys, V. Ellen, S. Ashot, M. Elizabeth, S. Justin, M. Charbel, P. Fernando (Washington, DC, USA)

    Objective: A retrospective records review of 9 patients that failed screening for a clinical trial was performed to examine the co-morbid cardiac manifestations of PD…
  • 2016 International Congress

    Modulating neuronal activity in dopaminergic neurons to promote their survival

    M.A. Bernardi, N. Baffa-Trasci, O. Gershanik, M.E. Avale, J.E. Ferrario (Caba, Argentina)

    Objective: To manipulate the activity of dopaminergic (DA) neurons in culture using pharmacological and molecular tools to promote their survival. Background: Parkinson's disease is a…
  • 2016 International Congress

    Constipation in early de novo Parkinson’s disease: Prevalence and correlates with clinical features, imaging and non-imaging biomarkers

    G. Pagano, F. Niccolini, M. Politis (London, United Kingdom)

    Objective: To explore the association between constipation and clinical features, imaging and non-imaging biomarkers in early de novo (untreated) Parkinson's disease (PD) patients. Background: Constipation…
  • 2016 International Congress

    A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity

    L.V. Kalia, K. Menezes, Y. Zhang, S. Ishikura, N. Tran, H. Chau, A.M. Lozano, S.K. Kalia, J.G. Culotti, S. Suo, W.S. Ryu (Toronto, ON, Canada)

    Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…
  • 2016 International Congress

    Difference of REM sleep behavior disorder between the onset of before and after Parkinson’s disease

    T. Nomura, Y. Inoue, K. Nakashima (Yonago, Japan)

    Objective: It is not clear that the onset of RBD (REM sleep behavior disorder) affect clinical characteristics of PD. A cross section study comparing clinical…
  • 2016 International Congress

    Cell-surface expression of dopamine transporter facilitates the uptake of α-synuclein

    J. Kobayashi, T. Hasegawa, S. Yoshida, N. Sugeno, R. Oshima, A. Kikuchi, A. Takeda, M. Aoki (Sendai, Japan)

    Objective: We determined whether increased expression of DAT have an impact on the uptake of α-synuclein (αS). Background: The endocytosis of dopamine transporter (DAT) controls…
  • 2016 International Congress

    Bcr-Abl tyrosine-kinase inhibitors (B-ATKI) and Parkinson’s disease (PD)

    E.A. Shamim, S.F. Baker, F.F. Liu, K.K. Mane, J.G. Layug, S. Vupputuri, C.C. DiStasio, S.M. Khandhar, C. Neff, S. Van Den Eeden, C. Lungu, R. Cooley, H.S. Martel, C. Chen, J. Dorman, M.A. Sinkiewicz, J. Klingman (Largo, MD, USA)

    Objective: Looking through the Kaiser Permanente National Parkinson's disease Registry, generated through the electronic medical records (EMR), we took a first step in looking at…
  • 2016 International Congress

    Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies

    J.V. Leikas, T.M. Kääriäinen, A.J. Jalkanen, M. Lehtonen, T. Rantamäki, M.M. Forsberg (Kuopio, Finland)

    Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…
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