Disease-modifying effect of Zonisamide with the induction of BDNF and TrkB expression
Objective: To evaluate to predictors of the disease-modifying effect of drugs on Parkinson’s disease (DM-PD) according to long-term therapeutic investigation, especially regarding the non-dopaminergic agent…Tremor’s Glove – An Innovative Electrical Muscle Stimulation Therapy to Treat Intractable Tremor in Parkinson’s Disease Patients: A Randomized Sham-Controlled Trial
Objective: To investigate the efficacy of a novel EMS device (Tremor’s glove) for reducing intractable resting hand tremor in PD. Background: Intractable resting hand tremor is…ON-time evolution following one-year open-label opicapone: BIPARK-I study
Objective: ON-time evolution following 1-year, open-label (OL), once-daily (QD) opicapone (OPC) treatment in patients with Parkinson’s disease (PD) on levodopa-therapy and with motor fluctuations. Background:…Results From a Phase 1b Multiple Ascending-Dose Study of PRX002, an Anti–Alpha-Synuclein Monoclonal Antibody, in Patients with Parkinson’s Disease
Objective: To evaluate PRX002 in patients with PD in a double-blind, placebo-controlled, phase 1b multiple ascending-dose study. Background: PRX002 (RG7935) is an investigational monoclonal antibody…Manual and Verbal guidance during the balance training based in virtual reality is essential for therapeutic results in people with Parkinson’s disease: a randomized clinical trial
Objective: To compare the effects of balance training in Virtual Reality (VR) supported by manual and verbal guidance (MVG) versus an identical training in absence…Randomized Parkinson’s Trial of GDNF Administered via Intermittent Intraputamenal Convection-Enhanced Delivery.
Objective: Assesing the neurorestorative effect of GDNF. Background: GDNF is a potent neurotrophic factor. A previous placebo-controlled trial, however, at 6 months, failed to demonstrate…The Importance of Ultrasonographic Evaluation in the Diagnosis of Dysphagia in Parkinson Disease
Objective: Dysphagia occur frequently in Parkinson’s disease. It include usually some problems to pharyngeal phase. Background: The aim of this study was to compare the…A Preliminary Study: Validity and Reliability of Parkinson Fatigue Scale (PFS) in Turkish Patients with Parkinson’s Disease (PD)
Objective: The purpose of this study was to investigate the validity and reliability of the Turkish version of PFS. Background: The PFS is a 16-item…The effect of early STN-DBS in PD patients on axial symptoms: a 2-year randomized controlled trial (EARLYSTIM-Gait analysis)
Objective: This study assesses the effect of STN-DBS in early PD patients on axial symptoms compared to BMT. Background: In well-selected candidates, STN-DBS offers symptom…A Preliminary Study: Validity and Reliability of Turkish Version of Fatigue Severity Scale (FSS) in Patients with Parkinson’s Disease (PD)
Objective: The aim of this study was to evaluate the validity and reliability of the Turkish version of FSS. Background: Fatigue is a frequent, non-motor…
