Targeting TLR4 for disease modification in multiple system atrophy: Experimental evidence
Objective: To assess the efficacy of toll-like receptor 4(TLR4) agonists to ameliorate the functional and neuropathological phenotype of a transgenic mouse model of multiple system…Progression of microglial activation and neuroinflammatory responses in a transgenic mouse model of multiple system atrophy
Objective: Our aim was to characterize the progression of microglial activation during disease progression in a transgenic mouse model of multiple system atrophy (MSA). Background:…Deep brain stimulation may lead to dramatic worsening of slowly progressive multiple system atrophy: A clinico-pathological series and review of the literature
Objective: The aim of the present study is to describe one of the largest series of histologically proven multiple system atrophy (MSA) patients, who underwent…Imaging correlates of hypodipsia in progressive supranuclear palsy
Objective: Aims of the present study were• to confirm hypodipsia as a characteristic feature of PSP and• to offer hypothesis on the pathological substrate for…The score changes of clinical symptom assessment scales for multiple system atrophy in 2-3 years
Objective: To examine the extent of disease progression for multiple system atrophy (MSA) during relatively long duration. Background: The knowledge of MSA natural history is…Heart rate variability and sympathetic skin response are useful in the evaluation of Parkinson’s disease, AMS, and Parkinson plus syndrome, but underutilized in daily clinical practice
Objective: Assess the heart rate (HR) coefficient of variance (CV) in three conditions: supine, active standing and during deep breathing; and measure the sympathetic skin…A longitudinal observational study of a cohort of patients with PSP/CBD: The JALPAC project
Objective: To identify PSP/CBD progression biomarkers both to improve understanding of disease etiology and course, and to provide crucial tools to enhance the likelihood of…Could tonic chin electromyogram density be a potential marker for differentiating atypical Parkinsonian syndromes from Parkinson’s disease among alpha-synucleinopathies?
Objective: The study aimed to examine whether the video-polysomnography (vPSG) could provide some clues for differentiating atypical Parkinsonian syndromes (APS) from Parkinson's disease (PD) among…Apraxia of speech as the initial manifestation of progressive supranuclear palsy
Objective: We report a patient with apraxia of speech as the initial symptom who finally developed a progressive supranuclear palsy. Background: Progressive supranuclear palsy (PSP)…High frequency of mutations in the glucocerebrosidase (GBA) gene among Ashkenazi Jews with dementia with Lewy bodies
Objective: The objective of this study was to characterize, clinically and genetically, anAshkenazi Jewish cohort of patients diagnosed with DLB, looking for the association with…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.