Adaptive Deep Brain Stimulation Guided by Electrophysiological Mapping for Stimulation-Induced Gluteal Dystonia in Parkinson’s Disease
Objective: To describe the use of electrophysiologically guided adaptive deep brain stimulation (aDBS) and directional volume of tissue activation (VTA) shaping to manage stimulation-induced focal…An Elevation in the Serum Biomarker pTau-181 May Identify Progressive Supranuclear Palsy Pathology
Objective: To report three cases of progressive supranuclear palsy (PSP) with significantly elevated pTau-181 levels on serum testing. Background: According to the MDS-endorsed PSP Study…Lead Asymmetry and Axial Symptom Response to Deep Brain Stimulation in Parkinson’s Disease: A Synthetic Pilot Modeling Study
Objective: To evaluate whether bilateral DBS lead placement asymmetry captures clinically meaningful correlates of motor outcomes, particularly freezing of gait (FoG) and balance to establish…Pulse-Width Dependent Motor Performance in Deep Brain Stimulation of Subthalamic Nucleus in Parkinson’s Disease: Evidence for a Kinematic Optimum Near 50 µs in Hand Movement
Objective: Objective: To identify pulse-width (PW) optima for motor performance using quantitative video kinematics in patients with Parkinson's disease (PD) undergoing subthalamic nucleus deep brain…Advancing Mobility-Related Activities of Daily Living Monitoring in Parkinson’s Disease: A Systematic Review of Wearable Sensor Technologies
Objective: To systematically review current evidence on wearable sensor devices for the objective monitoring of mobility-related ADLs in patients with PD. Background: Detecting Activities of…Healthcare Utilization and Economic Burden in Patients with Friedreich’s Ataxia: Baseline Results of the PROFA Study
Objective: The study aimed to investigate healthcare utilization, costs, and the distribution of costs across ambulation levels among patients with Friedreich's ataxia. Background: Friedreich's ataxia…Continuous subcutaneous levodopa infusion in advanced Parkinson’s disease: a descriptive real-world cohort study
Objective: To describe clinical characteristics, treatment indications, safety profile, and treatment persistence in patients with advanced PD treated with continuous subcutaneous levodopa infusion. Background: Continuous…Reducing Cost and Operative Time in DBS with a Consolidated Workflow: A Time-Driven Activity-Based Costing Analysis
Objective: To show that a consolidated patient specific workflow significantly improved operative efficiency and reduced personnel costs for deep brain stimulation (DBS) implantation, without compromise…Data Driven Clinical Insights from Longitudinal Cloud-Aggregated Neural Data to Inform a Real-World Adaptive DBS Programming
Objective: Characterize clinical workflow insights gained from expanded access to neural data via a cloud connected platform in adaptive DBS. Background: Adaptive deep brain stimulation…Remote Digital Deployment of a Validated Psychosis Screener in Parkinson’s Disease: Real-World Feasibility and Screening Yield
Objective: To evaluate rapid remote deployment of the Self-Administered Screening Questionnaire for Parkinson's Disease-Associated Psychosis (SASPAP) and assess whether screening identifies unmet need for clinician…
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