Machine Learning-Driven Analysis of Epigenetic Signatures in Juvenile Huntington’s Disease: Investigating Histone Modification Dynamics
Objective: To investigate the role of histone modifications in Juvenile Huntington’s Disease (JHD) using machine learning, aiming to identify novel epigenetic biomarkers predictive of disease…Clinician Guided Multimodal Kinematic AI System for Objective Assessment in Parkinson’s Disease
Objective: To evaluate the feasibility of developing a novel Multimodal Kinematic Artificial Intelligence (MKAI) system, uniquely guided by expert physician evaluation notes, to generate objective,…Diagnostic Sensitivity of a Shortened Accelerometry-Based Functional Tremor Battery
Objective: As most functional tremor battery tests rely on accelerometric data, we aimed to evaluate the diagnostic sensitivity of a shortened, accelerometry-only version of the…ALPHA-FIT: Slowing cognitive decline in alpha-synucleinopathies by enhancing physical activity
Objective: To evaluate the effects of increased physical activity on cognitive decline in patients with isolated REM sleep behavior disorder (iRBD). Background: Physical activity has…Impact of Hula on Balance Outcomes in Parkinson’s Disease
Objective: This study aims to determine the impact of a 12-week Hula program on balance in patients with Parkinson’s Disease (PD) and to investigate changes…Movement Disorder Phenotypes in Neuronal Antibody–Mediated Autoimmune Encephalitis
Objective: To characterize movement disorder phenotypes in neuronal antibody–mediated autoimmune encephalitis (AE) and assess associations with specific antibody subtypes. Background: Neuronal antibody–mediated AE is a…Parkinson’s Disease Genetics: From Monogenic Causes to Polygenic Risk and Clinical Translation
Objective: To systematically review recent advances in the genetics of Parkinson’s disease (PD), focusing on the mechanisms of major causal genes and biological insights derived…Interest in Clinical Trial Participation in Parkinson’s Disease: Insights from a Nationwide Registry
Objective: To compare demographic, clinical, and socioeconomic characteristics of patients with Parkinson’s Disease (PD) who declared interest in participating in clinical trials with those who…Sensitivity of AI-Derived Video-Based Digital Biomarkers to Motor Progression in Parkinson’s Disease
Objective: To determine whether video-based digital biomarkers derived from standardized motor tasks are sensitive to longitudinal progression in Parkinson’s disease (PD). Background: Bradykinesia is a…Longitudinal motor network responses to pallidal DBS in cervical dystonia: an ongoing DBS-fMRI study
Objective: This longitudinal MRI study in cervical dystonia uses functional MRI (fMRI) to evaluate neural mechanisms underlying clinical response to deep brain stimulation (DBS), with…
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