Heterozygous PINK1 p.G411S mutation increases risk for Parkinson’s disease (PD)
Objective: To investigate the possible disease-association and pathogenic mechanisms of heterozygous PINK1 mutations from a genetic, functional, and structural perspective. Background: It has been postulated…Mitochondrial Hsp90 inhibitor G-TTP triggers PINK1/parkin-dependent mitochondrial quality control
Objective: To characterize the response of cells treated with Gamitrinib-triphenylphosphonium (G-TTP) a mitochondrial targeted inhibitor of the chaperone Hsp90. Background: Upon dissipation of the mitochondrial…Falls in Parkinson’s disease: Beware the short, slow steps
Objective: To determine if step length influence falls in Parkinson's disease (PD) patients. Background: Falls are major cause of disability in PD. The objective of…Cortical impairment as marker of dementia risk in probable REM sleep behavior disorder in Parkinson’s disease
Objective: To assess utility of Parkinson's disease-cognitive rating scale (PD-CRS) to detect Mild cognitive impairment (MCI) and dementia risk in a Parkinson's disease (PD) subpopulation.…Stabilometry characteristics as objective Parkinson’s disease progression biomarkers
Objective: We aimed to find stabilometry characteristics, which may be used as disease progression and postural instability early development markers. Background: Balance and gait disorders…Generation and characterization of midbrain organoids from iPSCs of familial Parkinson’s disease
Objective: To generate and characterize human pluripotent stem cell (iPSCs) - derived midbrain cerebral organoids of patients with Parkinson's disease. Background: Parkinson's disease is a…Cyclic glycine-proline increased in the cerebrospinal fluid of Parkinson’s patients after supplementation of blackcurrant anthocyanins: Potential biomarker for treatment
Objective: We evaluated the changes of insulin-like growth factor-1 bioavailability in the Parkinson's disease patients after 28 day supplementation of blackcurrant anthocyanin. Background: Elevated insulin-like…In idiopathic Parkinson’s disease: The effect of using L-dopa on peripheral nerves
Objective: Idiopathic Parkinson's disease (IPD) is a chronic neurodegenerative disorder. Most of the clinicians believe that it is limited with motor and cognitive disorders. However,…Cortical role in the freezing of gait in Parkinson’s disease
Objective: In this study, we aimed to investigate the neural underpinning of freezing of gait (FOG) in Parkinson's disease (PD), especially the role of the…Association of Parkinson’s disease severity and cortical and subcortical cognitive markers
Objective: To assess cortical and subcortical dysfunction in several stages of Parkinson's disease (PD) using the Parkinson's disease-cognitive rating scale (PD-CRS). Background: Cognitive impairment in…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.