Elucidating the demographic distributions and implications of GBA1 gene variants in Parkinson’s Disease.
Objective: Estimating the distribution of GBA1 variants and estimating GBA1 odds ratios for Parkinson’s disease in the UK-based population. Background: Mutations in GBA1 are an…Stimulation-Induced Laryngospasm During Awake Ventral Intermediate Nucleus Deep Brain Stimulation for Essential Tremor
Objective: To report a rare case of acute laryngospasm during intraoperative stimulation in VIM-DBS surgery. Background: Deep brain stimulation (DBS) of the ventral intermediate nucleus…HOPFIT: proactive recognition of older in-patients with advanced Parkinson’s disease improves palliative care outcomes and patient autonomy
Objective: The Holistic Parkinson’s and Frailty Integration Team (HoPFIT) is a multi-disciplinary in-patient service at Addenbrooke’s Hospital in Cambridge, United Kingdom, aiming to improve outcomes…Association of IL-6 and Lp(a) with Incidental Parkinson’s Disease Risk and Motor Severity After Stroke: A Prospective Cohort Study
Objective: To investigate whether inflammatory and lipid-related biomarkers (IL-6 and Lipoprotein(a) [Lp(a)]) are associated with the risk of developing Parkinson's disease (PD) and motor severity…Binge-eating as an Initial Presentation for the Diagnosis of Chorea-acanthocytosis
Objective: - Background: Chorea-acanthocytosis (ChAc) is an autosomal recessive disorder associated with mutations or deletions in the VPS13A gene on chromosome 9q21, which codes for…Automated Differentiation for Early Parkinsonism Using Clinical Structural MRI: A Multicenter Study
Objective: To develop and validate a T1-weighted structural MRI–based machine learning model for differentiating Parkinsonism at early-to-mid stage and generalize the model to routine anisotropic…Baseline Characteristics of Participants Enrolled in a Randomised Pilot Study of Enhanced Tai Chi for Parkinson’s disease
Objective: To describe the baseline characteristics of participants enrolled in a pilot randomised controlled study evaluating Enhanced Tai Chi for Parkinson’s disease (NCT07297368). Background: Exercise-based…Age-Modulated Gait Adaptations to Progressive Fatigue in Parkinson’s Disease
Objective: To investigate the effect of progressively increasing perceived fatigue on gait biomechanics in people with Parkinson’s disease (PD), considering the potential moderating role of…IMU Insole-Derived Gait Digital Biomarkers in idiopathic RBD and Parkinson Disease
Objective: To identify IMU insole-derived gait biomarkers differentiating healthy controls (HC), idiopathic rapid eye movement sleep behavior disorder (iRBD), and Parkinson disease (PD) during a…Quantifying longitudinal clinical trajectories of disease progression and prognosis in Primary Brain Calcification, the Padua PBC-cohort experience
Objective: To characterize longitudinal progression of motor and neuropsychological symptoms in PBC and to identify predictors of disease prognosis Background: Primary Brain Calcification (PBC) is…
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