Characterisation of early onset Parkinson’s disease in UK cohorts
Objective: To identify and describe the genetic features of UK early onset Parkinson’s disease (EOPD) patients. Background: EOPD with age of onset (AAO) <36 years…Quantifying longitudinal clinical trajectories of disease progression and prognosis in Primary Brain Calcification, the Padua PBC-cohort experience
Objective: To characterize longitudinal progression of motor and neuropsychological symptoms in PBC and to identify predictors of disease prognosis Background: Primary Brain Calcification (PBC) is…Microstructural and functional abnormalities of Amygdala subregions in Parkinson’s Disease with impulse control disorder
Objective: To investigate amygdala subregional alterations associated with impulse control disorders (ICD) in Parkinson’s disease (PD) and to clarify the mechanistic role of the superficial…Development of a Parkinson’s Disease Dyadic Multidisciplinary Illness Management Program: Protocol for PATH Parkinson
Objective: This study describes the development of partnership-based assistive team-based healing (PATH) Parkinson, a chatbot-based multidisciplinary mobile application (app) designed for patient–caregiver dyads with Parkinson’s…Clinical Outcome Assessments for Spasticity and Functional Performance in Spastic Paresis: Which Scales Should Be Used?
Objective: To review clinical outcome assessments (COAs) used to evaluate spasticity and functional impairment in spastic paresis and provide recommendations for their use in clinical…Functional Movement Disorders in a Public Health System: Misdiagnosis, Diagnostic Delay, and Healthcare Utilization in 61 Patients
Objective: To characterize diagnostic delay, patterns of misdiagnosis, and healthcare utilization before diagnosis of FMD in patients evaluated in a tertiary public hospital in Peru.…Quanti-tau-PET Study of PI‑2620 Tau-PET Quantification in Progressive Supranuclear Palsy
Objective: *Establish a quantitative analysis framework for PI‑2620 tau-PET in progressive supranuclear palsy (PSP);*Compare tau-PET uptake in PSP versus control subjects;*Assess correlations with clinical variables…A Diffusion MRI Neurodegeneration Index for Lewy Body Dementia & Alzheimer’s disease
Objective: To develop a diffusion MRI-based neurodegeneration index using free-water imaging and assess its ability to quantify neurodegenerative burden in Lewy body dementia (LBD) and…Randomized Controlled Trial Comparing Adaptive versus Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease; Closed Loop Optimization of Deep Brain Stimulation Effect in Parkinson’s Disease (CLOSE-PD study)
Objective: To evaluate whether adaptive deep brain stimulation (aDBS) of the subthalamic nucleus (STN) is more efficacious than continuous DBS (cDBS) in Parkinson's disease (PD)…Investigation of Sex-based Differences in the Utility of IgG Index as a Potential Predictor of Cognitive Impairment in Parkinson’s Disease
Objective: Determine if there are sex-based differences in associations of baseline (BL) immunoglobulin G (IgG) index with development of cognitive impairment (CI) among cognitively normal…
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