Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…Feasibility of home-based assessments using wearable sensors and videos in children with GNAO1-related movement disorders: A pilot study
Objective: To investigate feasibility of home-based assessments in GNAO1-related dystonia, using wearable sensors and home-videos. Background: Movement disorders in GNAO1-associated disorder are common, with dystonia…Understanding the Impact of the Small Scale Levodopa-Entacapone-Carbidopa-Intestinal-Gel Pump on Everyday Experiences of People Living with Parkinson’s Disease: A Mixed-Methods Evaluation
Objective: This study aims to qualitatively evaluate the impact of switching from the conventional Levodopa-Carbidopa-Intestinal-Gel (LCIG) pump to the smaller sized Levodopa-Entacapone-Carbidopa-Intestinal-Gel (LECIG) pump on…Biomarker-Informed Survival Modelling Using Plasma Neurofilament Light and Clinical Predictors in a Prospective Multiple System Atrophy Cohort
Objective: To develop and evaluate multimodal survival models in MSA integrating clinical features with plasma NfL. Background: Progression in Multiple System Atrophy (MSA) is highly heterogeneous. Robust…Patient-Derived α-Synuclein Kinetic Subtypes Drive Distinct Pathological Propagation Patterns and Brain Network Alterations in Parkinson’s Disease Mouse Models
Objective: To validate whether patient-derived α-synuclein (α-Syn) aggregates with distinct kinetic properties produce differentiated pathological propagation patterns, brain network functional alterations, and behavioral phenotypes in…Trancranial Sonography Reveals Striatal Neurodegeneration in the Prodromal Phase of X-linked Dystonia-Parkinsonism
Objective: To use transcranial sonography (TCS) to detect striatal and substantia nigra abnormalities in patients with X-linked dystonia-parkinsonism syndrome (XDP), non-manifesting carriers (NMC) of the…Microstructural and functional abnormalities of Amygdala subregions in Parkinson’s Disease with impulse control disorder
Objective: To investigate amygdala subregional alterations associated with impulse control disorders (ICD) in Parkinson’s disease (PD) and to clarify the mechanistic role of the superficial…Pulsatile Striatal Dopamine Dynamics Drive Levodopa Induced Dyskinesia In Advanced Parkinson Disease
Objective: To determine how pathological striatal dopamine fluctuations relate to dyskinesia and motor output in levodopa induced dyskinesia. Background: Levodopa induced dyskinesia is a major…Painful legs moving toes spectrum disorders – a systematic review
Objective: To investigate the clinical characteristics of painful legs moving toes (PLMT) spectrum disorders. Background: Classic PLMT is a rare movement disorder characterized by continuous involuntary…Dysregulation of lysosomal lipid microdomains impairs autophagic flux in GBA-associated Parkinson’s disease
Objective: To investigate the link between lipid dysregulation and lysosomal dysfunction in GBA-associated Parkinson’s disease (GBA-PD) and explore potential metabolic rescue strategies. Background: Mutations in the GBA gene…
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