Was the deep brain stimulation surgery successful? Is it the same for the physician and the patient ?
Objective: To compare the physician`s assessment and the patient perception of the definition of successful therapy in STN DBS. Background: Although the treatment of Parkinson's…A multiple-dose thorough QT study to evaluate the effect of ampreloxetine on cardiac repolarization in healthy subjects
Objective: To characterize the effect of therapeutic and supratherapeutic doses of ampreloxetine on cardiac repolarization in healthy subjects. Background: Ampreloxetine is a potent NE reuptake…Effects of Unilateral and Bilateral DBS of STN, GPi on Voice in PD Patients
Objective: To study the effects of Deep Brain Stimulation (DBS) of subthalamic nucleus (STN) and globus pallidus interna (GPi) on voice in patients with Parkinson’s…Investigating Digital Biomarkers in Parkinson’s Disease
Objective: Our objective is to investigate potential digital biomarkers of Parkinson’s Disease (PD) for early diagnosis and treatment. Background: Parkinson’s disease presents difficulty with early…Bilateral subthalamic nucleus deep brain stimulation in Parkinson’s disease: preoperative predictors of speech worsening
Objective: To find preoperative predictive factors of short-term postoperative speech worsening in a large cohort of consecutive PD patients treated with bilateral STN-DBS. Background: Subthalamic…Comparing the outcome under General Anaesthesia (GA) and Monitored Anesthesia Care (MAC) of Subthalamic Nucleus (STN) – Deep Brain Stimulation (DBS) Surgery for Parkinson’s Disease (PD) in Hong Kong – A single center experience
Objective: To evaluate any difference in the clinical outcome under GA and MAC of STN DBS surgery Background: Traditionally, DBS surgery is performed under MAC…LRRK2 Inhibition by BIIB122/DNL151 Demonstrates Robust Target and Lysosomal Engagement: Pharmacokinetics, Pharmacodynamics and Safety in Phase 1 and Phase 1b Studies in Healthy and Parkinson’s Participants
Objective: To characterize the pharmacokinetics (PK), pharmacodynamics, safety, and exposure-response (E-R) relationships of BIIB122/DNL151 to inform on clinical dose selection. Background: Increased LRRK2 kinase activity…Parkinson’s disease in patients with Gaucher’s disease – causation or association?
Objective: To do a systematic review to find the risk of Parkinson's disease in patients with Gaucher’s disease. Background: Parkinson's disease (PD) is the second…Dopamine Receptor Gene Polymorphism in L-Dopa Induced Dyskinesia- A Study from Eastern India
Objective: We intended to find the frequency of Single Nucleotide Polymorphism (SNP) rs6280 in DRD3 gene in PD patients with and without Levodopa Induced Dyskinesia…How do recently diagnosed individuals with Parkinson’s self-monitor their Parkinson’s symptoms between consultations?
Objective: To determine how recently diagnosed people with Parkinson's monitor their Parkinson's symptoms in between medical consultations. Background: Patients monitoring symptoms and reporting them accurately…
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